2.5 mg cbdDecember 15, 2021
(Note: All prices are accurate as of publication and are subject to change.)
$55 per container.
Expressed in milligrams (mg), CBD dosage largely depends on the conditions and symptoms you’re trying to treat and your unique endocannabinoid system, which is associated with motor control, behavior, emotions, the nervous system and homeostasis. CBD dosage remains an area of active research—more large, high-quality studies are needed in different populations to determine appropriate dosing, efficacy and safety guidelines.
Penguin CBD Gummies.
50mg/mL ×0.05mL/drop = 2.5mg/drop.
On Penguin's Secure Website.
On Penguin's Secure Website.
With this CBD oil dosage calculator as your guide, you would find that you needed to consume 10 drops, or 0.5 milliliters, to reach 25 milligrams. And if you intend to consume 25 milligrams daily, you can expect this particular bottle to serve as a 60-day supply.
FDA-approved Epidiolex administers CBD orally as a liquid to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex. The dosage of Epidiolex is determined by taking the patient’s weight in kilograms (kg) into account.
1500mg÷30mL = 50 mg/mL.
Penguin CBD Oil.
In many medical studies on CBD, you see administered doses reach hundreds of milligrams a day, which sounds severe compared to our starting dosage example of 25 milligrams. However, Steven Phan, founder of Come Back Daily, a CBD dispensary in New York, points out that patients in these studies are often dealing with serious flare-ups and pain-inducing conditions compared to everyday dispensary customers.
Consumers can choose from a variety of CBD products, from oils to gummies to vapes to capsules. But figuring out the safe and effective CBD dose for an individual is a complex decision.
Here’s how to find the right CBD dosage for you and how to consume it safely.
Without FDA approval, there is little guidance in the U.S. on how much CBD a person should consume for various conditions.
Penguin CBD Capsules.
$45 per container.
Popular ways to take CBD include:
CBD oil, on the other hand, makes it easier, to begin with a small dose. But calculating CBD oil dosage can be less straightforward. Oils and tinctures tend to come in a dropper bottle and, typically, only the total liquid volume and CBD contents are listed on the label. For example, the label might simply state there’s 1,500 milligrams of CBD in the 30-milliliter bottle.
Like with any substance, you can take more CBD than your body can handle. Studies show doses up to 1,500 milligrams a day have been well-tolerated, but every person is different  Bergamaschi MM, Costa Queiroz RH, Zuardi AW, Crippa JAS. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current Drug Safety. 2011;6(4):237-49. . Ingesting too much CBD can cause unpleasant side effects, such as dry mouth, nausea, diarrhea, upset stomach, drowsiness, lightheadedness and general disorientation. While rare, liver damage can also occur.
If you’re still not sure where to start, mydosage.com offers a questionnaire and CBD calculator to help you based on your specific symptoms and usage goals.
However, CBD oil might change the way your body breaks down certain medications. This could make the drugs have a stronger or weaker effect, which can be dangerous. Talk to your doctor before you use CBD oil, especially if you take any medicine or have liver disease.
Outside of these two disorders, CBD's effectiveness in treating seizures is uncertain. Even with Epidiolex, it's unclear if the anti-seizure effects are from CBD or some other factor.
CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should consult their healthcare provider before taking CBD oil and use it with caution. Regular blood liver enzyme level checks are recommended.
The men who took 300 mg of CBD oil showed less anxiety than those given a placebo. Interestingly, the men who took 100 mg or 600 mg of CBD oil didn't have these results.
In June 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution.
There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays.
A 2017 study reported that only 31% of CBD products sold online were correctly labeled. Most contained less CBD than advertised, while 21% had significant amounts of THC.
There are no guidelines for the proper use of CBD oil. CBD oil is usually taken by placing one or more drops under the tongue and holding it there for 30 to 60 seconds without swallowing.
Some experts suggest CBD may help treat cannabis and nicotine dependence, but more research is needed.
The rats that got CBD experienced less inflammation and nerve pain (pain caused by damage to your nerves).
CBD oil might help relieve stress, anxiety, seizures, drug withdrawal, and nerve pain. But taking higher doses doesn't always mean they'll have a stronger impact. Also, many studies on CBD have been done on animals, so it's hard to tell if these same effects will apply to people.
People that support the use of CBD claim that CBD oil can treat a variety of health problems, including:
Clinical research has shown that CBD oil can trigger side effects. The severity and type can vary from one person to the next.
To determine an exact dose of CBD, remember that each drop of oil equals 0.05 mL of fluid. This means that a 30-mL bottle of CBD oil will have about 600 drops. If the concentration of the tincture is 1,500 mg per mL, one drop would contain 2.5 mg of CBD (1,500 mg ÷ 600 drops = 2.5 mg).
Instead, CBD influences other receptors, like the opioid receptors that control pain. It also affects glycine receptors. These control serotonin, a brain chemical known as the “feel-good” hormone.
Possible Side Effects.
For the study, 57 men took either CBD oil or a placebo (sugar pill) before a public-speaking event. The researchers based anxiety levels on measures like blood pressure and heart rate. They also used a fairly reliable test for mood states called the Visual Analog Mood Scale (VAMS).
The researchers reported that CBD showed promise in treating people with opioid, cocaine, or psychostimulant addiction.
CBD's exact mechanism of action is unclear.
To avoid interactions, tell your healthcare provider and pharmacist what medicine you're taking. This includes prescription, over-the-counter, herbal, or recreational drugs.
Here are a few tips to help you find the best CBD oil:
The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL (or more).
A 2015 review of studies in the journal Neurotherapeutics suggests that CBD might help treat anxiety disorders.
However, at higher doses, too much activity at the receptor site can lead to the opposite effect. This would take away the helpful effects of CBD.
Epidiolex is used to treat two rare forms of epilepsy in children under 2: Dravet syndrome and Lennox-Gastaut syndrome. These are very rare genetic disorders that cause lifelong seizures that start in the first year of life.
Unlike the THC that's in marijuana, CBD oil doesn't get you high. It contains a chemical called cannabidiol that might help relieve stress, anxiety, drug withdrawals, and nerve pain.
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.
Common side effects include:
CBD oil contains CBD mixed with a base (carrier) oil, like coconut oil or hemp seed oil. The bottled CBD oil is called a tincture and is sold in different concentrations.
There aren't many study trials that look at CBD's anxiety-relieving effects in humans. One of the few is a 2019 study published in the Brazilian Journal of Psychiatry .
CBD oil may reduce the risk of heart disease by relieving high blood pressure in some people, per a 2017 study in JCI Insight.
There are tons of CBD products on the market, from lotions you rub on to capsules you swallow and tinctures you drop under your tongue. All these are made similarly: By extracting CBD, or cannabidiol, from a cannabis plant and then diluting it with a carrier, such as coconut oil, explains Capano. The way you choose to use it is totally a matter of preference and might require some experimentation.
If your needs are not quite so urgent, you might opt for a tincture; you’ll still feel the effects soon—usually within 20 minutes to an hour—since the liquid quickly absorbs into your bloodstream after you drop it under your tongue. This usage allows the CBD to bypass a first pass through your liver that capsules require before you feel their effects.
One caveat: Most vaporizers use either propylene glycol or vegetable glycerin (PG or VG). Those are added ingredients used as carrier oils, and unfortunately we don’t know yet whether they’re safe to vaporize, warns Capano. If immediate pain relief isn’t a priority, another option, like a tincture, cream, or capsule (which take longer to set in), might be the safer way to go.
How do I use CBD?
To make sure you’re getting a legit product, research the brand before purchasing from it and find out where it sources its CBD. If you can find a company that’s vertically integrated—meaning they have control over the growth of their plants—that’s ideal, notes Capano. (It’s not essential, though, and might be difficult to find a vertically integrated brand, as only a handful of companies in the U.S. are.)
“There’s some evidence out there that CBD can adversely affect a damaged liver, and there’s other evidence that shows it can be helpful—it seems to depend on the underlying cause of liver damage,” Capano adds. If you already have liver issues, talk with your doc, keep a close eye on your dosage, and be sure to monitor hepatic enzymes every three months.
You can’t OD on CBD, but dosage is personal. “More does not necessarily mean better,” warns Capano. “The response dose curve looks like a bell, so you want to hit the top of the bell without going over.” When figuring out your optimal dose, add a bit more every three days or so and see how you respond. If you get to a point where you don’t feel any extra benefit (or feel worse), you’ve gone too far; dial it back a bit the next day.
Nixing your nerves is one of the top reasons people are turning to CBD products (along with lessening pain and help sleeping). There’s still research to be done on how exactly it works to calm anxiety, but one thing we do know is that it blocks an enzyme called FAAH, which works to lower a fatty-acid neurotransmitter called anandamide, explains Capano.
Your ideal dosage also varies based on how you’re taking it—you’ll need less from a tincture than a capsule, for instance, because tinctures have a greater bioavailability (meaning more gets into your bloodstream and causes an effect).
For oils, creams, and other topical treatments—which are a great option for eczema, burns, or other skin conditions—“dosage depends on the concentration of the product, but generally just apply a small amount, as needed,” suggests Capano. Topicals also can help with headaches or migraines if you apply it at onset. And if getting your CBD with a vaporizer, start small. “You need less from a vaporizer and will have a very rapid onset,” she says. For this reason, she recommends trying just 2.5 mg at first.
How long does CBD take to work?
While all that combines to mean CBD has magical pain-slashing properties for certain aches, it’s not ideal for every kind. It’s a great, effective therapeutic option for chronic pain and pain prevention (e.g. frequent headaches, ongoing back pain that’s lasted more than a week), says Capano. “But if you have an acute injury, like a broken bone, CBD is not going to be a substitute for morphine in the hospital; those really strong narcotic painkillers have their place.”
The real concern when it comes to side effects, says Capano, is whether or not the CBD in your medicine cabinet is legitimate. You first need to find out if it’s even real CBD, as synthetic can be dangerous. Then look into how the plants are grown, how the product is manufactured, and what quality-assurance tests the brand conducts to ensure safety and the elimination of pesticides, chemicals, microbes, and molds. “It’s an unregulated industry, and there’s a lot of great branding and marketing out there, but unfortunately transparency is rare and not knowing what you’re getting is common,” warns Capano. “Usually that risk just means wasting your money, but it could be harmful, if there are dangerous chemicals in there, for example.” Contact the company with these questions; any reputable brand will be willing to provide customers with all these details.
Unlike smoking a joint, using CBD won’t leave you with a giggling fit or the munchies. It can, however, make you sleepy. “The most common side effect is drowsiness, so don’t take it for the first time and get behind the wheel or head into a big presentation,” advises Capano. Wait to see how your body responds, just in case. In some cases, CBD can exacerbate heartburn or lead to mild allergic reactions, such as hives (though this is likely a reaction to the carrier oil added to the CBD, says Capano). Using CBD can also cause diarrhea or change in appetite or weight, according to a recent German study.
That said, if you’re dealing with chronic pain and are already on medication for it, talk with your doctor about combining those traditional meds with CBD. More than 50 percent of long-term opioid users who added CBD to their treatment were able to reduce their opioid use and 90 percent of them had better quality of life within two months, according to research Capano recently conducted, which is pending publication. “We know that CBD is effective with pain and it’s safe to use with opioids—plus, it can help with withdrawal symptoms as you lower opioid use,” she says. “There’s pretty good data that CBD can be a treatment for substance abuse disorders. We should be motivated to use something that’s safer and doesn’t have the risk of dependency or overdose.”
How much CBD should I use?
If you’re in a big city, you’ve likely seen CBD all over—from chic pop-up shops to your corner bodega. If you’re in a small town, you can probably find it in a brick-and-mortar shop too, as lots of small, independent pharmacies are carrying CBD products now. But if you do have trouble tracking it down in person, you can easily order online and have it shipped to any state (since U.S.-grown CBD is legal nationwide per the Farm Bill). But keep in mind: “There are so many online retailers, you have to do your homework,” says Capano.
For the non-scientists among us, by blocking FAAH, CBD can help increase your level of anandamide. And that’s a big deal when you’re looking for a mood boost. This neurotransmitter (the same one that leads to the elusive runner’s high) is named after the Sanskrit word for joy, bliss, or happiness. Basically, says Capano, “CBD makes our natural bliss molecule work better for us.”
“Most people using full-spectrum CBD are taking no more than 40 to 60 mg a day, and we haven’t demonstrated drug interactions at those levels,” says Capano; you’d likely need to use upwards of 20 mg per kilogram of your bodyweight before seeing interactions. But talk with your doctor before combining CBD with any drugs you’re already on, especially if you take blood thinners or antidepressants, advises Capano.
Like Capano explained above, the perfect dose varies from person to person. It also depends on a few things—the first being whether you’re using an isolate or full-spectrum product. Isolate products are pure CBD while full-spectrum products contain multiple cannabidinoids and oils, vitamins, and more natural compounds. “With full-spectrum products, you need a lower dose—and that might prevent drug interactions and will be easier on your liver,” says Capano.
Yes, and it may be your best bet if you’re hoping to achieve quick pain relief. Of all the options for taking CBD, vaping has the most rapid onset; you’ll feel its effects within minutes, says Capano. “Some people use CBD daily for prevention of a migraine, but if they feel one coming on, vaping might be a good way to get an almost-immediate CBD delivery to abort a migraine quickly,” she says.