can i take melatonin and cbdDecember 15, 2021
Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.
While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.
Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included.
Does the form of CBD matter?
Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.
People considering or taking CBD products should always mention their use to their doctor, particularly if they are taking other medications or have underlying medical conditions, such as liver disease, kidney disease, epilepsy, heart issues, a weakened immune system, or are on medications that can weaken the immune system (such as cancer medications). A pharmacist is a great resource to help you learn about a potential interaction with a supplement, an herbal product (many of which have their own drug interactions), or an over-the-counter or prescription medication. Don’t assume that just because something is natural, it is safe and trying it won’t hurt. It very well might.
Doubling up on side effects.
CBD can alter the effects of other drugs.
The ECS regulates many vital bodily functions, which help in maintaining balance within the body.
The effects of CBD oil for sleep or insomnia are heavily dependent on the dose.
In other words, this hormone plays a crucial role in regulating your sleep-wake-up cycle, also known as the circadian rhythm.
Connections between CBD oil and melatonin taken together.
There is still no solid validity or reliability that taking CBD oil and melatonin together helps better sleep. So, only your doctor or relevant health professional can guide you on what’s good for you and your condition.
The good news is that CBD has not been reported to have any adverse or fatal side effects. So, while you’re free to experiment, it’s advisory to keep it moderate as it can and does show mild side effects.
The production of melatonin in the body is commonly affected by factors such as age and exposure to artificial light.
In order to understand more about how these elements work together, let’s recap on both components.
When taken in small amounts, it may act as a stimulant. However, taking large doses can induce sedation.
Now taking high doses of melatonin, especially anything higher than 5mg, is seen to be ineffective. So, taking a dose higher than 5mg will be unnecessary and is not worth the side effects.
This is why figuring out the right dose is important with CBD oil.
CBD Oil dosage.
As such, both CBD oil and melatonin combined can offer you a more sustained level of quality sleep, with minimal waking patterns.
CBD oil is commonly used to help with anxiety, stress, mood swings, immunity, appetite, digestion, metabolism, inflammatory responses, insomnia, other sleeping disorders, and different chronic pains.
There is indeed a connection between CBD oil and melatonin.
It’s important to clarify that both CBD oil and melatonin together can interact with other medications you may be taking. So, before following any of the proceeding information, we suggest you look to obtain your doctor’s consent.
Secondly, the MT1 and MT2 melatonin receptors and CB-1 and CB-2 CBD receptors that influence sleep fall into the same group called G-protein coupled receptors.
How CBD oil and melatonin work.
It’s this connection between CBD oil and melatonin that makes their benefits on sleep complement one other.
These receptors are the ones that inform or send signals to your brain that it’s time to sleep. Also, melatonin helps with the following as well:
This can make your day inactive and drowsy. Your dose should help you with a quality sleep at night to make sure you are alert, active, productive, and happy during the day.
Can I take CBD oil with melatonin? CBD oil and melatonin are considered safe to take together. They have sleep benefits that complement each other, especially for insomnia. Take a 1-mg melatonin tablet, split it into two and take half each night. Combine with 10mg of CBD oil or take 0.25/0.50 mg for every one pound weight as a guide .
CBD oil works by interacting with the endocannabinoid system (ECS) through cannabinoid receptors found all over the body.
This is especially relevant to current generations as they are regularly exposed to artificial light through phones, tablets, and computers. Therefore, melatonin production is treating affected.