cbd and adderallDecember 15, 2021
Before you decide to try it, it is important to learn more about what CBD oil is, what the research says about what it can do, and what benefits and side effects it might have for alleviating symptoms of ADHD.
If you are thinking of taking CBD, you should also be aware that while it is usually well-tolerated, it may lead to some side effects.
A 2020 study found that higher doses of medical cannabis were associated with a decreased use of ADHD medication in adults. The products containing a higher dosage of CBD were associated with lower ADHD scores.
Reasons to Consider Using CBD.
Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology.
Some research suggests that very high doses may pose a risk of liver damage. In a study where mice were given very high doses of CBD, researchers observed that there was an increased risk for liver toxicity. Of course, more research is needed to determine if these same risks apply to humans.
While the Centers for Disease Control and Prevention (CDC) reports that between 70 and 80% of kids who have ADHD experience a reduction in symptoms after taking stimulant ADHD medication, they can cause side effects including sleep issues, decreased appetite, and mood changes.
While the evidence that CBD oil might be useful as a treatment for ADHD remains scant, it may be useful for managing some of the symptoms that are sometimes associated with the condition. ADHD is often associated with a variety of co-occurring conditions including anxiety and depression.
Some people who advocate for the use of CBD oil for ADHD suggest that:
Some research has found that CBD may play a role in counteracting some of the negative side effects associated with THC.
CBD for ADHD Symptoms.
If you decide to try CBD oil for ADHD or other reasons, it is important to purchase it from reputable sources. Products containing CBD are frequently mislabeled, and since there is no federal regulation over these products, it is difficult to know exactly what you are getting.
Whether the use of CBD oil might contribute to later marijuana use remains unknown. However, marijuana can potentially have negative effects on things like attention and motivation. Young people who smoke marijuana can also experience lasting detriments to cognitive ability and IQ.
CBD oil may cause a number of side effects. Although many of these symptoms are mild, it's important to note some of the common complaints:
Side effects may be more common at higher doses, although research suggests that CBD appears to be safe and well-tolerated at doses up to 1,500 mg per day. It is also important to note that CBD can impact the metabolism of certain medications.
CBD May Reduce ADHD Symptoms.
While CBD is growing in popularity, its legal status varies depending on where you live. All states permit CBD, but many have restrictions based on the THC levels found in the product. It is important to note that while many states have passed laws legalizing CBD and other cannabis products, any product containing more than 0.3% THC is illegal according to federal law.
The memory and attention impairments that are associated with the use of cannabis are one potential concern.
The Federal Trade Commission Act prohibits manufacturers from claiming that a product can prevent, treat, or cure a disease unless such claims are backed by reliable scientific studies.
When it comes to ADHD, people who are thinking of trying CBD oil need to understand that there is a major lack of research on the topic. There are no randomized controlled trials that indicate whether it is effective or ineffective. There is also no research comparing CBD oil to other treatments for ADHD.
While CBD oil does not have psychoactive properties, it may also contain small amounts of THC, which could potentially exacerbate some ADHD symptoms.
Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.
Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included.
Doubling up on side effects.
While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.
CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.
People considering or taking CBD products should always mention their use to their doctor, particularly if they are taking other medications or have underlying medical conditions, such as liver disease, kidney disease, epilepsy, heart issues, a weakened immune system, or are on medications that can weaken the immune system (such as cancer medications). A pharmacist is a great resource to help you learn about a potential interaction with a supplement, an herbal product (many of which have their own drug interactions), or an over-the-counter or prescription medication. Don’t assume that just because something is natural, it is safe and trying it won’t hurt. It very well might.
Does the form of CBD matter?
CBD can alter the effects of other drugs.
CBD acts through these receptors as a negative allosteric modulator. CBD also modulates neural circuits such as the dopaminergic mesocorticolimbic system, which is involved in addiction and drug-seeking behaviors .
You should, however, always consult your doctor if you’re on any medication before adding any other drug — even a natural one — to avoid possible interactions.
CBD may decrease the effects of amphetamine (Adderall) and may slow down its metabolism [1,2].
2. CBD May Cause Slower Elimination (Metabolic Competition)
CBD and amphetamine (Adderall) are generally safe at a low therapeutic dose but can be hazardous when used in high doses for recreational use (not recommended). It could also become dangerous over time if both substances are taken together on a regular basis.
Amphetamine is prescribed for ADHD and increases attention span and focus, and helps control behavior problems. It may also help with organization and listening skills. It’s illegal to use amphetamine for recreational purposes.
CBD may induce molecular modifications in the dopaminergic pathways via a secondary response mechanism to its effects on the endocannabinoid system. This modification, in turn, may attenuate the effects of amphetamine, which chiefly exerts its effects through the neurotransmitter dopamine.
Amphetamine (Adderall), on the other hand, is a psychostimulant drug. It increases the excitatory neurotransmitters — dopamine and norepinephrine — and causes wakefulness, euphoria, increased libido, and a better attention span.
Amphetamine is available in three forms:
Here’s a list of similar medications that share a similar level of risk when combined with CBD:
What Is Amphetamine (Adderall)?
With that said, CBD could make amphetamines ineffective for treating ADHD, which would negate the entire point of using the medication in the first place.
Amphetamine (Adderall) is classified as a nervous system stimulant. CBD and stimulants all share the same risk for interaction and side effects.
Amphetamine (Adderall) exerts its stimulatory effects by increasing the release of dopamine and norepinephrine, and to a lesser extent, increases serotonin.
Amphetamine (Adderall) has its benefits as well as side effects. The main factor that determines the severity of side effects is the dosage.
Does CBD Interact With Amphetamine (Adderall)?
CBD has antipsychotic and anxiolytic properties, whereas amphetamine is a psychostimulant.
Most medications, as well as CBD, are metabolized by the liver before they’re eliminated from the body. CBD competes for the same enzymes involved with metabolizing amphetamines, which can cause the processing of both substances to become slower. This may lead to elevations in both CBD and amphetamines in the bloodstream with repeated use.
The cannabinoid receptors CB1 and CB2 are distributed throughout the body in areas like the brain, organs, connective tissue, endocrine glands, and the immune system.
Amphetamines (Adderall) can be beneficial but should be avoided in certain circumstances. Anyone with the following conditions should not use it.
Amphetamine (Adderall) is available with a doctor’s prescription to treat ADHD and narcolepsy. Its use for any other purpose is illegal.