cbd and depression

December 15, 2021 By admin Off

Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.

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Chief Medical Officer at Yesterday Wellness and Integrative Medical Cannabis Physician; co-author of Cannabis and CBD for Health and Wellness; Board Member of American Academy of Cannabinoid Medicine.

Additionally, CBD can have benefits in social settings. Researchers found CBD decreased anxiety in patients with social phobia by lowering activity in the amygdala and increasing prefrontal cortex activation, the two areas of the brain involved with regulating anxiety. And, it may also help reduce major angst before a stressful event, such as public speaking. Studies, including one published in Neuropsychopharmacology , have shown that CBD administered before a public speech significantly reduced overall anxiety, cognitive impairment, and performance anxiety.

The ECS is like Big Brother, constantly keeping an eye on things so when something’s not working right, it can take action. For example, let’s say your body generates a whole lot of heat after a workout. In this case, endocannabinoids bind to receptors, which then alert the ECS that it’s time to get your body to cool down by producing sweat.

This is one of the great mysteries; the optimal CBD dose is not an exact science. Doctors say there isn’t one universal dosage of CBD because different people (and different animals, for that matter) respond to different dosages of CBD. What experts also agree on, however, is that CBD works best when taken on a regular basis (daily). And the best way to know what works for you is to start on a low dose and titrate up if needed. It may not take as long as for someone with mild symptoms to feel the effects as someone who is dealing with more severe anxiety or depression. The goal is to find the lowest, most effective dose, so work with your doctor and give yourself time to figure it out.

How Much CBD Should I Take?

So, you’ll need to do a bit research. Look for integrative and holistic physicians who understand how to support and educate you in the use of phytomedicines.

While there’s a solid amount of scientific research that shows CBD can be effective for anxiety in animals, as well as anecdotal evidence and case reports that show it may be beneficial for alleviating anxiety in humans, there is less data on the effectiveness of CBD for depression, though there have been some promising animal studies. For example, a 2018 study on rats published in NeuroscienceNews showed that just a single dose of CBD helped to reduce symptoms of depression for up to one week. Researchers believe CBD helps repair neural circuitry in the prefrontal cortex and hippocampus, which get damaged as a result of depression.

Dry-herb Vaporizing: For patients who are feeling all kinds of jittery and need more immediate relief, some experts recommend vaping CBD through a dry-herb vaporizer, which heats up dried CBD flowers (unlike traditional vape pens which require oil-based cartridges). These are relatively safe because they avoid the by-products produced from burning plant material and can be set to a desired temperature that allows you to get the most benefit from the CBD you are consuming.

To complicate matters, CBD is only FDA-approved for use in one medication, Epidiolex, which is used to treats the seizures associated with two rare forms of epilepsy. Because it’s largely unregulated, navigating the world of CBD can feel like a long, strange trip. And since you can’t be sure exactly what you’re getting, word to the wise: Consume with caution and always consult with your doctor.

Experts believe careful CBD dosing may help temper the anxiety-induced racing thoughts that can cause disrupted sleep as well as panicked awakenings during the night. While CBD may not help someone with depression directly, it may benefit in other ways that can improve their mood or their ability to manage the condition overall. For example, sleep disruption and depression are closely linked. More than 90% of depressed patients complain about difficulties falling asleep, sleep disruption, or early morning awakenings. CBD can also be used to treat parasomnias, sleep disorders like jaw grinding, sleepwalking, or nightmares, and it cuts the time it takes to fall asleep.

CBD can be very effective for some people and not make a dent in others. Though it shouldn’t be a stand-alone treatment, it may be a beneficial co-pilot to other anti-anxiety meds or antidepressants, particularly in the time before the effects of antidepressants start to kick in.

Also keep in mind, anxiety and depression have a complicated relationship. Both are conditions related to poor sleep, pain, and mood regulation. When we experience more anxiety, we experience more pain, and when we are feeling more depressed, we feel more anxious. It’s a chicken/ egg-like scenario. Here’s where CBD may fit in:

Additionally, anxiety and stress inhibit GABA, a naturally occurring brain chemical that directs neurons to slow down or stop firing. This neurotransmitter essentially tells the body to chill out by helping to induce sleep, relax muscles, and create a sense of calm. Some scientists believe CBD can help modulate GABA so the body returns to its regularly scheduled programming.

CBD may also have a positive interaction with serotonin receptors in the brain. In a study on mice published in CNS & Neurological Disorders , researchers found that when depressed rodents were given CBD, it impacted the way their brains’ chemical receptors responded to serotonin, producing an antidepressant effect.

The Society of Cannabis Clinicians has a provider finder on their website where you can look for health-care professionals in your area who are well-versed in CBD. The Association of Cannabis Specialists is another great resource for researching cannabis clinicians near you. Another option: Hit up your local CBD dispensary. Oftentimes, they may be able to tell you which physicians are sending their patients in to buy CBD.

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In the world of herbal remedies CBD, short for cannabidiol, is like the second coming among enthusiasts. Praised for its healing prowess—for everything from pain and insomnia to gastrointestinal issues and inflammation—the cannabis-born compound is fast developing cult-like status. Not only are physical health benefits reported, but more and more people are turning to CBD to help with mental health conditions—particularly anxiety and depression. And the research is promising. A review in Frontiers in Immunology found that CBD creates a calm in the brain that’s visible on scans—doctors can actually see the angst dissipate. There’s still a lot to learn about CBD’s impact on mood, but we’ve got all the intel to help you weed through the field.

Author of Medical Cannabis and CBD: A Physician’s Guide for Patients; Internal Medicine and Primary Care Doctor.

While the research and anecdotal evidence is promising, because CBD is unregulated, it’s difficult to study, and any given sample can differ from the next, which means it’s also tricky to determine just how effective it is. Factors like the severity of depression and anxiety, as well as genetics play a role. And the benefits aren’t universal either.

Member of the American Cannabis Nurses Association; co-founder of Cannabis Care Team.

If you’re considering CBD, before you make a move, talk with your primary care physician or mental health provider. Remember, CBD is not a substitute for talk therapy or medication. It’s also not a magic cure-all and may work better for some people than for others.

Found mostly in the brain, the CB1 receptor is thought to tame central nervous system inflammation and help modulate the effects of serotonin, a neurotransmitter that oversees mood. In fact, the way many antidepressants work is by increasing serotonin in the brain.

Maybe you’re already an expert on CBD, so feel free to skip to the section below; if you need a crash course, follow right along. CBD is one of two primary chemical entities (cannabinoids) found in the cannabis plant (the other one is tetrahydrocannabinol, THC). Unlike THC, which is what causes you to get high, CBD has no psychoactive effects (one reason why so many people are trying it). CBD derived from hemp differs from marijuana by its THC content. Hemp has less than the legal limit of 0.3% THC, while marijuana contains more than 0.3% THC.

How Effective Is CBD for Anxiety & Depression?

Experts believe the most effective form of CBD is an oil or tincture (alcohol-based solution) used sublingually (placed under the tongue). A sublingual preparation ensures the cannabinoids get distributed throughout the body. For patients who are feeling all kinds of jittery and need more immediate relief, some experts recommend vaping CBD through a dry-herb vaporizer, which heats up dried CBD flowers. These are relatively safe because they avoid the by-products produced from burning plant material and can be set to a desired temperature that allows you to get the most benefit from CBD you are consuming.

CBD and cannabis-related curriculum is not (yet) taught in medical schools, so it can be a challenge to find a doctor who’s knowledgeable about the landscape. Most physicians don’t know much about the science behind medical cannabis and how to integrate it within a patient’s treatment plan.

Now, here’s how CBD comes into play. When you take CBD, you’re basically supporting the work the ECS is already doing to help your body function on the regular. Researchers believe CBD works to alleviate symptoms of anxiety and depression by binding to one of the main receptors within the ECS, the CB1 receptor.

And, the best way to know what works for you is to start on a low dose and titrate up if needed (follow the recommended dosage instructions on the bottle and talk to your doctor). It may not take as long as for someone with mild symptoms to feel the effects as someone who is dealing with more severe anxiety or depression. Ultimately, the goal is to find the lowest, most effective dose. Work with your doctor and give yourself time to figure it all out.

CBD is thought to be relatively safe—a position that’s backed by the World Health Organization—but there can be some mild side effects including:

Sleep disruption and depression are also closely linked. More than 90% of depressed patients complain about difficulties falling asleep, sleep disruption, or early morning awakenings. CBD may improve their mood or their ability to manage the condition overall. CBD can also be used to treat parasomnias, sleep disorders like jaw grinding, sleepwalking, or nightmares, and it also cuts the time it takes to fall asleep.

CBD is thought to positively influence the processes that regulate our mood, sleep, and pain perception, among others. These processes need to function properly, so we feel better, sleep more soundly, and experience less pain. Anxiety and depression are conditions related to poor sleep, pain, and poor mood regulation because the endocannabinoid system isn’t working to the best of its ability.

Experts believe careful CBD dosing may help temper anxiety-induced racing thoughts that can cause disrupted sleep as well as panicked awakenings during the night. (In some people, though, too much can make anxiety worse, so be sure to dose slowly and carefully).