cbd and platelets

December 15, 2021 By admin Off

Some studies indicate CBD—and other cannabinoids—may have an anticoagulant effect by suppressing production of blood platelets, which is an obvious concern for anyone with a bleeding disorder. Another issue is how CBD interacts with other medications, which is uncertain and needs more study.

CBD is extracted from the cannabis plant and added to oils, creams and balms, liquids for vaping, pills and even candies like mints and gummies.

Cannabidiol (CBD) is one of several chemical compounds, called cannabinoids, found in the cannabis plant. Another cannabinoid is delta-9-tetrahydrocannabinol (THC), the compound in marijuana that makes you high.

More broadly, general safety is a gray area when it comes to CBD oil. Production of CBD oil products is unregulated, so it can be difficult to know exactly what you’re getting. The US Food and Drug Administration tested several brands of CBD oil and says that “many were found to not contain the levels of CBD they claimed to contain.” Other research has found some CBD products contained levels of THC that could cause intoxication. In an exhaustive report on CBD oil, Consumer Reports magazine says it may be safer to buy CBD in states where medical and recreational use of cannabis is legal, as standards are likely to be stricter in these locations. Another tip is to look for CBD from producers who post the results of third-party testing of their products.

Little research has been done into the health effects of CBD. However, more studies are underway, and health agencies such as the National Institutes of Health and the World Health Organization agree more research is needed. In the US, just one prescription drug has been approved that contains CBD as its active ingredient: Epidiolex, which reduces seizures in people with two rare forms of epilepsy.

What’s the evidence that it works?

In most states, CBD is legal as long as it is extracted from the hemp variety of the cannabis plant and it contains no THC (the 2018 federal farm bill legalized cultivation of hemp). You can check the laws in your state at the website of the National Organization for the Reform of Marijuana Laws (NORML).

Unlike THC, CBD does not get you “stoned.” Some report that CBD’s effects include both physical and mental relaxation, reduced soreness and inflammation, and improved focus. However, some users say they don’t feel anything.

Last October, a New York Times headline asked a question many people across the country have had on their minds: “Why Is CBD Everywhere?” CBD oil, scientifically known as cannabidiol oil, has been heavily marketed as a cure-all for everything from inflammation and chronic pain to anxiety and insomnia. For people with bleeding disorders, CBD oil may seem appealing to try. But what is it exactly, and how much evidence is there that it actually works?

CBD may help relieve pain, anxiety and insomnia, but it also may not. If you’re interested in using it, be sure to check with your healthcare team first so they can advise you on how to use it and monitor its effects.

How is CBD oil made?

What is CBD oil?

CBD can inhibit the body’s ability to metabolize certain drugs, leading to an overall increase in processing times and higher-than-expected drug levels in the blood. Interestingly, CBD oil is not alone in its effect on drug metabolism. Grapefruit, watercress, St. John’s wort, and goldenseal all have a similar impact on drug metabolism. If you are taking a medication affected by CBD, you should consult with your doctor to make sure that it is safe for you to supplement with CBD or to discuss adjusting the dosage on your medications so that you can use both products safely.

Though federal law prohibits the cultivation, sale, and use of marijuana, several states and territories have legalized marijuana for medical purposes and recreational use. Some states only approved the use of CBD alone for medicinal purposes.

Cannabidiol (CBD) is one of the many active ingredients derived from the plant species Cannabis sativa . There are several strains of the Cannabis sativa plant, with the two most common being marijuana and hemp. Industrial hemp has a high percentage of the phytocannabinoid CBD and a very low concentration (less than 0.3%) of THC (tetrahydrocannabinol). THC is the psychoactive, mood-altering component associated with the “high” of marijuana. CBD is not associated with psychoactive effects and does not have the same risk of abuse or dependency. CBD is growing in popularity and was most recently approved by the FDA for very specific medical uses.

On June 25, 2018, the FDA approved Epidiolex (cannabidiol), a highly purified pharmaceutical CBD formulation, as a treatment for seizures associated with Dravet syndrome and Lennox-Gastaut syndrome in patients aged 2 years and older. Epidolex is the first FDA-approved treatment for Dravet and is considered a significant advancement for this patient population. The exact mechanism of action for the treatment of seizure is unknown.

The most common side effects reported with the use of CBD include appetite alteration, sleepiness, gastrointestinal disturbances/diarrhea, weight changes, fatigue, and nausea. Uncommon or rare adverse events include thrombocytopenia (low blood platelets), respiratory infections, and alteration of the liver enzymes.

FDA-Approved Formulations for Epilepsy.

A growing body of evidence suggests that CBD has properties that can improve overall health and manage specific conditions. CBD has anti-inflammatory properties, which may be beneficial for arthritis and other pain. It is also shown to have effects on brain chemistry, which may be helpful for those suffering from depression, anxiety, or insomnia. Finally, early human studies suggest CBD could play a role in treating opioid addiction and other types of substance abuse.

In December 2018, the Hemp Farming Act was signed into law in the United States. This act removed the Schedule I controlled-substance classification from hemp (THC less than 0.3%) and classified it as an agricultural product. CBD products derived from the industrial hemp plant are now available in all 50 states in many different formulations, and they are touted to treat a wide range of conditions from pain and inflammation to depression and epilepsy. CBD is available in oil, tincture, vaporization liquid, and pill forms and can be purchased both in stores and online. The Hemp Farming Act does not apply to products and formulations derived from the marijuana plant, which is still considered a Schedule I controlled substance by the federal government.

With all of the promising therapeutic applications for CBD, caution should be exercised when using CBD for medical therapy. Since CBD is considered a supplement and not a drug, it is not held up to the same level of scrutiny when it comes to purity and dosing, or in proving efficacy and safety. It is unclear which doses and which dosage forms work for best for each condition, making dosing recommendations a guess, at best.


Experimental and Anecdotal Uses.

The effects were assessed of delta’THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on 14C labelled serotonin release from normal platelets, when incubated with patient’s plasma obtained during migraine attack. A statistically significant inhibitory effect (p greater than 0.005) of 14C serotonin release was found at 10(-5)M, 10(-6)M, 10(-7)M delta’THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on 14C serotonin release from normal platelets using the same delta’THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.