cbd balm for pain

December 15, 2021 By admin Off

The only thing that comes close is a Phase 2 clinical trial using a proprietary CBD transdermal gel (meaning it’s meant to go through the skin into the bloodstream) in 320 patients with knee osteoarthritis over 12 weeks, which has not been peer-reviewed to date. Unfortunately, in almost all of the study’s measures of pain, those who received CBD didn’t have statistically different scores from those who got placebo. But “they found some reductions in pain and improvements in physical function,” Boehnke says.

Another study published in 2016 in the European Journal of Pain also looked at arthritis in rats but did so with a topical formulation of CBD. After the rats received an injection into one knee joint to model arthritis, they received a gel that contained either 10 percent CBD (in four different total amounts) or 1 percent CBD (the control) on four consecutive days. The gel was massaged into the rats’ shaved backs for 30 seconds each time.

“Cannabidiol is a super messy drug,” Ziva Cooper, Ph.D., research director of the UCLA Cannabis Research Initiative in the Jane and Terry Semel Institute for Neuroscience and Human Behavior and the department of psychiatry and biobehavioral sciences, tells SELF. “It has lots and lots of targets and it’s not clear how much of its effects on each target contribute to the potential pain relieving effects.”

The most common medical reason for which people report using CBD is to manage chronic pain, followed closely by managing arthritis or joint pain. But does it actually work?

First off, we don’t know much about the correct dose of CBD needed for a pain-relieving effect. The doses in the rat studies that were effective were pretty large (for a rat, obviously). And the human participants in the Phase 2 clinical trial we mentioned received 250 mg of synthetic CBD topically per day—as much as many consumer topical CBD products contain in a single jar.

Here’s what the research says about using CBD for pain.

“It actually is a very promiscuous compound,” Kevin Boehnke, Ph.D., research fellow in the department of anesthesiology and the Chronic Pain and Fatigue Research Center at the University of Michigan, tells SELF. “It will bind to receptors in multiple different pathways,” which makes it difficult to know how it might cause noticeable effects.

Cannabidiol, commonly referred to as CBD, is a cannabinoid, a type of compound found in cannabis (marijuana). Unlike the more well-known cannabinoid THC (tetrahydrocannabinol), CBD does not produce a high.

Why does the body have receptors for compounds in cannabis? Well, it doesn’t exactly. Cannabinoids like THC and CBD are similar enough to compounds that your body naturally makes, called endocannabinoids, that they can interact with this system. Normally, the endocannabinoid system is thought to play a role in a variety of functions in the body, helping to regulate things like parts of the immune system, the release of hormones, metabolism, and memory.

Both THC and CBD act on a system of receptors in your body called cannabinoid receptors. You have cannabinoid receptors throughout your body and, so far, researchers have identified two major types: CB1 (found primarily in the central nervous system, including parts of the brain and spinal cord) and CB2 (found mainly in immune system tissues). Interestingly, both have been found in skin. Researchers have also found that while THC can bind to and activate both types of receptors, CBD seems to modulate and somewhat block the effects of CB1 and CB2 receptors. So, any effect that CBD has on CB receptors may actually be more related to regulating and even counteracting some of the actions of THC and other cannabinoids in the brain.

All of this points to how hard it is to study the specific effects of CBD on its own—which might be why it’s tempting to claim that it’s the cure for everything without a whole lot of research to actually back up all of those claims.

But if you’re reading this, you are probably not a rat, which means these results aren’t directly applicable to your life. Although we know that rats do share much of our physiology—including CB1 and CB2 receptors—these studies don’t really tell us if humans would have the same results with CBD.

More recent research suggests that many of CBD’s effects may occur outside of CB receptors, Jordan Tishler, M.D., medical cannabis expert at InhaleMD in Boston, tells SELF. In fact, according to a recent review published in Molecules, CBD may have effects on some serotonin receptors (known to play a role in depression and anxiety), adenosine receptors (one of the neurological targets for caffeine), and even TRPV-1 receptors (more commonly associated with taste and the sensation of spiciness).

Personally, I always keep a few jars of it at my desk to help with the shoulder and neck muscle tension inherent in a job consisting mainly of typing and holding a phone next to my face. But it turns out that the research behind these claims is pretty sparse, to say the least. Here’s what you need to know before you give topical CBD a try.

“There’s really no substitute for doing proper human studies, which are difficult, expensive, and ethically complicated,” Dr. Tishler says. And we simply don’t have them for CBD and pain.

You don’t need me to tell you that CBD (cannabidiol) is everywhere. You can eat it, you can drink it, you can vape it, you can even bathe in it. And although there’s still plenty to learn about this fascinating little compound, fans of it claim that it has some pretty impressive benefits—particularly when it comes to managing pain.

What is CBD?

Then the researchers measured the inflammation in each rat’s knee joint, the level of CBD that made it into their bloodstream, and their pain-related behaviors. They found that the rats that were given the two highest doses of CBD showed significantly lower levels of inflammation and lower pain behavior scores compared to those that got the control. The two lower doses didn’t show much of an effect.

But that’s not quite as exciting for CBD as it sounds: “We don’t know cannabidiol’s effects on its own,” says Cooper, who was part of the National Academies committee that put together this report. “[The conclusions about cannabis and cannabinoids] were based on what we know about THC or THC plus cannabidiol.”

When the National Academies of Sciences, Medicine, and Engineering evaluated decades of cannabis research, they concluded that "in adults with chronic pain, patients who were treated with cannabis or cannabinoids are more likely to experience a clinically significant reduction in pain symptoms."

In fact, the most compelling research they found for using cannabinoids for pain came from a large review and meta-analysis published in JAMA in 2015. For the study, researchers looked at results from 79 previous studies of cannabinoids and various medical conditions, including chronic pain. However, of those studies, only four involved CBD (without THC)—none of which were looking at pain. So although we might assume that CBD is doing something to help address pain—according to the studies involving the whole cannabis plant—we don’t have great evidence to prove it.

It’s totally possible (and actually pretty likely) that any effect you get from a commercially available topical CBD product is a placebo effect or related to some other aspect of the product. But there are a few things going on here that are more complex than they seem.

“It might be that cannabidiol by itself is helpful for pain, but at this point we don’t know that,” Cooper says.

If you’re ingesting something that only has CBD in it and no THC, you won’t have significant effects in the brain. This is why CBD is often referred to as being “non-psychoactive,” although that’s clearly a bit of an oversimplification because it does do something to the central nervous system.

So…is CBD cream just an expensive placebo?

The studies we do have about CBD for pain are all animal studies. For example, in a 2017 study published in Pain, researchers gave rats an injection into one of their knee joints to model osteoarthritis. Rats then either received doses of CBD or saline directly into an artery in the knee joint. Results showed that, after receiving CBD, rats showed less inflammation in the joint area and fewer pain-related behaviors (like shaking or withdrawing the affected paw or not being able to bear weight in that paw) compared to those that received saline.

And even though the lotion was applied topically in the rat study, it wasn’t applied locally to the knee. Instead, the researchers were really using the topical application to get it into the rats’ bloodstream, or what’s called systemic administration. But you’d likely need a different dose for it to be effective locally (if you applied it just to your aching shoulder, for instance) in a human. We have no idea what that dose should look like.

CBD pain creams that are effective soothe painful muscles and release tight muscles. CBD creams are used by some people after they exercise or participate in sports activities. In addition, CBD creams are used by some to target particular joints. The finest CBD creams have been shown to help with muscular relaxation.

We evaluated the top CBD creams available in 2021 based on all of the characteristics listed above.

The Relief + Recovery Cream from Medterra blends CBD with organic ingredients like menthol and arnica to create a topical CBD solution. Applying the lotion to your body provides a quick cooling effect while also improving muscle and joint health. Medterra’s Relief + Recovery Cream comes in three different strengths: 250mg, 500mg, and 750mg. Sunflower seed oil, aloe vera leaf juice, safflower seed oil, ginger, and lemon peel are among the formula’s key ingredients. The products are tested by a third party to ensure that they are THC-free. Simply use the cream regularly to reap the benefits of 99.6% CBD.

Bloom Hemp Topicals.

Some CBD lotions are oily, while others are difficult to use. Others are gentle on the skin and absorb fast. Over time, the finest CBD cream companies have improved their formula’s viscosity and absorbency.

The first product on our list that is more of a spray than cream is EirTree. EirTree, on the other hand, says that their mixture provides targeted muscle and joint relief. Doctors, chemists, and health specialists have all approved it. EirTree’s Skin Spray comes in five different varieties, including hemp and CBD versions. The HYPO CBD from EirTree comes in a 12mL container with a sprayer. EirTree’s Skin Spray has 900mg of CBD isolate per bottle, giving it one of the highest doses on this list. For example, 30mg is equal to two sprays of EirTree’s HYPO CBD. EirTree’s HYPO CBD Skin Spray isn’t inexpensive at $90 a bottle, but it can give targeted relief all over your body.

Some people are willing to spend $10 on a bottle of CBD cream. Others desire a cream that costs $150. Therefore, we included CBD creams for various budgets, including low-cost and high-cost creams with varying dosages.

Hemp balms, salves, creams, butter, lotions, and ointments are among the CBD topicals offered by Receptra Naturals. The Serious Relief line, which includes Serious Relief With Arnica sticks, body oils, and creams, is the company’s most well-known product lineup. Receptra Naturals created the cream with a mix of CBD and arnica to target inflamed regions of your body while promoting quick healing. The product is naturally perfumed with jasmine, ylang-ylang, and camphor, promoting fast muscle and joint healing while also opening pores.

Regardless, certain trials for skin illnesses including eczema, psoriasis, pruritus, and inflammatory ailments showed promising outcomes, according to the experts. According to researchers, endocannabinoid receptors, including the receptors targeted by CBD, can be found in the skin.

Affiliate Disclosure:

There have been no reports of CBD pain cream having any negative side effects. The majority of people can use CBD pain cream without having any negative side effects.

Natural Ingredients.

The amount of CBD in skin creams varies a lot. Some people prefer a high dose of CBD, while others find that a smaller dose provides equivalent results. Skin creams with a variety of dosage choices were our favorites.


CBD pain creams aren’t used to make you smell better. The creams are made to relieve discomfort. CBD pain creams, according to many people, ease pain like no other remedy they’ve tried. One of the most important criteria we utilized was pain relief. We distinguished between excellent and terrible CBD creams based on their capacity to reduce pain.

CBDistillery offers various CBD oils, gummies, and other products, including the CBDefine Skin Cream. Each jar contains 500mg of CBD extracted from hemp. In addition to CBD, CBDefine also contains active ingredients. These ingredients include extra virgin, organic coconut oil, organic olive oil, and organic sunflower oil. Also, they contain tea tree, frankincense, lavender, and rosemary essential oils are part of this formula. For optimal relief, CBDistillery suggests applying a generous amount of cream to the target area.

A: CBD topical treatment has been proven to have no significant adverse effects. It’s conceivable, though, that you’re allergic to some of the CBD cream’s ingredients, such as essential oils or plant extracts.

CBDistillery CBDefine Skin.

Like many other creams on our list, CBDFx’s Muscle and Joint Cream is a cooling mix containing menthol, white willow bark, and CBD. Caffeine is a component that we don’t find in other pain relief creams but is present in CBDFX’s formula. Each CBDFx Muscle and Joint Cream container contains 500mg to 3,000mg of CBD, depending on your preferred dose. CBDFx claims that the mixture targets muscular pains and joint pain with powerful anti-inflammatory plant extracts. Menthol cooling effect provides long-lasting pain relief, while white willow bark and caffeine are also proven natural pain relievers.

There are now more CBD pain creams available than ever before. CBD pain creams, however, are not all the same. Continue reading to learn about the best CBD pain creams, salves, and balms on the market in 2021.

Muscle & Joint Formula from CBDPure has 250mg of full-spectrum CBD in each tube. CBDPure added menthol and white willow bark to improve the recipe’s efficacy, which helps the mixture cool the targeted region and soothe sores, muscles, and joints. The company claims that a pea-sized quantity of their solution provides laser-focused impact. Apply a pea-sized quantity to the desired region and wait for the results to take effect. Each tube will set you back approximately $40. Jojoba seed oil, eucalyptus, and apricot extract are among the other ingredients in CBDPure’s Muscle & Joint Formula.

Some CBD lotions have a foul odor. Others have an overabundance of menthol, fooling you into thinking they’re delivering effective pain relief. However, each CBD pain cream listed above was personally sniffed, and fragrance played a factor in our rankings.

CBD pain creams enrich your skin with cannabidiol and other natural ingredients. The chemicals in the cream are applied topically to relieve pain and inflammation at the core.

In a 2018 study, researchers examined the impact of cannabinoids (including CBD) on pain and inflammation. Researchers found that CBD appears to assist the body manage pain and inflammation in diverse ways after evaluating dozens of studies on pain, inflammation, and CBD.