cbd disease

December 15, 2021 By admin Off

It’s also common for someone with CBD to experience personality changes, such as becoming apathetic, irritable, agitated or anxious.

Problems affecting the limb can include:

CBD typically affects one of the limbs at first. This is usually a hand or arm, but sometimes a leg.

Walking, balance and co-ordination may get worse. Many people have problems with their speech, which will become slow and slurred.

Some of the main symptoms of CBD are outlined below. Most people with the condition won’t experience all of these.

Mid-stage symptoms.

Some people with CBD also have dementia, although this doesn’t always occur, symptoms may include:

As CBD progresses, it may eventually start to cause problems in your other limbs.

The condition tends to develop gradually, which means it can be mistaken for another condition at first – such as Parkinson’s disease, dementia or a stroke.

Some people also develop problems with walking and co-ordination.

As CBD reaches an advanced stage, muscle stiffness will continue to get worse. People with the condition may lose the ability to move 1 or more limbs. Some people are unable to walk and need a wheelchair or assistance to transfer (such as help getting into and out of bed).

The symptoms typically become more severe over several years, although the speed at which they worsen varies.

Other problems people with advanced CBD can experience include:

As a result of swallowing problems, many people with CBD develop chest infections caused by fluid or small food particles falling down into their lungs (aspiration pneumonia), which can be life-threatening.

Early symptoms.

Advanced stages.

CBD is a very individual condition and the symptoms each person experiences vary. As CBD is a progressive neurodegenerative condition, symptoms gradually become worse over time.

CBD has similarities with Progressive Supranuclear Palsy (PSP). Some people with CBD go on to develop PSP, and vice versa.

Changes in personality, such as apathy, irritability, and decreased interest in things previously enjoyed may be noticed by family and friends.


Corticobasal Degeneration (CBD) is a rare type of parkinsonism that affects people from the age of 40, typically between the ages of 50 to 70. It tends to affect one side of the body more than the other initially, gradually spreading over a few years.

Diagnosis is usually based on the pattern of symptoms experienced and the exclusion of other conditions that may cause similar symptoms, such as Parkinson’s or stroke. Unfortunately, as with Parkinson’s, there is no single test or scan to diagnose CBD.

It is thought there may be some weak genetic link too but the risk of other family members developing CBD is very low.

Content last reviewed: March 2020.

Speech and communication problems : slow and slurred speech.

Cognitive and behavioural changes : thinking may become impaired, leading to memory problems and difficulty understanding and interpreting communication. It may also be difficult to carry out complex tasks that require planning ahead.


A diagnosis should be made by a specialist with experience in CBD, usually a neurologist. He or she may ask for a brain scan to rule out other causes, and they may also carry out tests to check memory, concentration, and understanding of verbal communication.

We would like to thank Prof Carlo Colosimo (Università La Sapienza, Rome, Italy) for his help in reviewing this infomation.

Swallowing difficulties : eating, drinking, and swallowing become progressively more difficult and food may ‘go down the wrong way’. This can lead to chest infections or pneumonia.

The most common symptoms are outlined below, but many people have only a few symptoms.


Movement difficulties.

CBD occurs when cells in specific parts of the brain – the cortex and basal ganglia – are damaged as a protein called tau builds up and over time causes harmful clumps. In normal brains, tau is broken down to avoid a build-up, but in CBD this does not happen.

There is currently no cure or treatment to stop CBD’s progression but medication and various therapies can relieve symptoms and improve quality of life.

More information and support is available from the Frontotemporal Dementia Support Group – FTDSG, The Association for Frontotemporal Degeneration – AFTD, and the Progressive Supranuclear Palsy (PSP) Association – PSP Europe.