cbd dosage for generalized anxietyDecember 15, 2021
A growing number of companies have begun selling supplements, salves, and other products containing CBD oil. They often tout these items as natural remedies for issues like anxiety and pain.
Similarly, CBD showed no effect on systolic blood pressure (the top number in a blood pressure reading) or persecutory ideation. This is a fear that someone is harming you or will in the future.
Cannabidiol may not reduce anxiety in healthy adults, according to a study published in Cannabis and Cannabinoid Research .
In doing so, they are taking a leap of faith. Scientists say more research is needed to learn how CBD oil might help treat conditions like anxiety.
Researchers gave different dosages of CBD to participants before a public speaking test. They found that subjective anxiety measures dropped with a 300 mg dose of CBD. This drop did not occur with either the 100 or 900 mg CBD dosages.
Harvard Medical School notes that all 50 states have laws on the books that legalize CBD "with varying degrees of restriction."
Cannabidiol is unlike tetrahydrocannabinol (THC). This other cannabis compound produces a “high.” CBD oil typically doesn’t contain THC, so it doesn’t have this effect.
Using CBD oil may cause a number of side effects. Ironically, one of these side effects can be anxiety. Others may include:
For example, scientists reported in Neurotherapeutics that CBD oil might ease some disorders, including generalized anxiety, panic, social anxiety, obsessive-compulsive, and post-traumatic stress disorders.
The uncertainty explains why it makes good sense to consult your healthcare provider before taking CBD oil. If your physician cannot recommend a brand, then he or she may be able to warn you off an irreputable brand.
If you were to plot this result on graph paper, it would form a bell, with 100 and 900 on the ends. Hence, the name of this pharmacology concept literally takes shape.
At the same time, not only do some products contain THC, a number of them had enough THC to cause symptoms like an increased heart rate. In this way, some CBD products can actually make anxiety worse.
A small study published in Neuropsychopharmacology determined that CBD may help reduce social anxiety. The ADAA defines this disorder as "intense anxiety or fear of being judged, negatively evaluated, or rejected in a social or performance situation."
Is CBD Legal?
Rather than self-treat, ask your healthcare provider about whether CBD oil can help you manage your anxiety. A physician is also in the best position to recommend a dosage that will be right for you.
CBD oil may interact with several medications, including benzodiazepines, calcium channel blockers, antihistamines, and some types of anti-epileptic drugs. If you take any of these medications, consult your healthcare provider before using CBD oil.
CBD does not appear to ease paranoia, however. A study published in the Journal of Psychopharmacology tested the effects of CBD in people with high paranoid traits.
Cannabidiol is a compound found in the cannabis plant. Its availability is soaring as cannabis is being legalized in more states across the country.
Researchers concluded this after testing participants' responses to negative images or words and threatening faces after they took oral CBD.
Other studies suggest CBD can reduce PTSD symptoms when consumed with THC  Bitencourt RM, Takahashi RN. Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials. Front Neurosci. 2018;12:502. . When taken together, the two compounds create what’s known as the “entourage effect,” where THC enhances the effects of CBD as CBD tempers the effects of THC, resulting in a more well-rounded experience  Ferber SG, Namdar D, Hen-Shoval D, et al. The “Entourage Effect”. Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. Curr Neuropharmacol. 2020;18(2):87-96. .
Eight years later, a 2019 test compared the efficacy of three CBD doses (150 milligrams, 300 milligrams and 600 milligrams) and a placebo in men taking an SPST  Linares IM, Zuardi AW, Pereira LC, et al. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2019;41(1):9-14. . Compared to a placebo, 300 milligrams of CBD significantly reduced participants’ anxiety during the speech, but the 150-milligram and 600-milligram doses did not. These results highlight how dosage can be highly variable and that more CBD isn’t necessarily more effective.
However, other trials suggest much lower doses are also quite effective in treating anxiety.
You may have to try different forms to determine what works best in addressing your anxiety. For instance, when it comes to the absorption of CBD in your bloodstream, vaping and smoking are more effective than edibles like gummies.
You also have to find the right CBD dosage for your anxiety. Experts suggest starting small and working your way up depending on how your body reacts.
CBD for PTSD and Phobia Therapy.
Some studies also suggest CBD can enhance the effects of exposure therapy—which assists patients in dissociating certain cues with a fear response—and cognitive behavioral therapy  Das RK, Kamboj SK, Ramadas M, et al. Cannabidiol enhances consolidation of explicit fear extinction in humans. Psychopharmacology (Berl). 2013;226(4):781-792.  Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825-836. .
The Food and Drug Administration (FDA) has yet to approve any CBD-based medications for anxiety. However, many studies indicate the substance can be an effective anxiolytic.
Without clear FDA guidance, optimal CBD use for anxiety varies from person to person. You may find one method works better for you over another. You can consume CBD in the following forms:
In 2011, a small trial-tested CBD on participants with generalized social anxiety disorder (SAD) and healthy control patients undergoing a simulated public speaking test (SPST), which is a common anxiety testing method  Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011;36(6):1219-1226. . Compared to a placebo, CBD significantly reduced anxiety and discomfort in the participants with SAD. In fact, their reduced anxiety levels were comparable to those of the control participants.
Many clinical trials jump right to testing high doses. Successful doses evaluated for anxiety relief specifically include:
Here’s what the science says regarding CBD’s anxiolytic properties, along with experts’ dosage guidelines and advice on how to take CBD safely.
Meanwhile, another 2019 study tested CBD in much lower doses than most other clinical studies—some participants consumed 25 milligrams a day while others consumed 50 milligrams or 75 milligrams a day  Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019;23:18-041. . Researchers thought higher doses might be too expensive for participants to maintain in their normal lives and that low doses would still prove effective. Indeed, anxiety decreased within the first month for most participants and remained low. Sleep quality also improved, although it fluctuated more than anxiety. Only three patients reported side effects.
In 2020, researchers tested the effects of CBD oil at varying doses across 397 patients with a variety of ailments  Gulbransen G, Xu W, Arroll B. Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand. BJGP Open. 2020;4(1):bjgpopen20X101010. . Participants with non-cancer pain or mental health-related symptoms experienced significant improvement in anxiety and depression, as well as in their abilities to complete their usual activities. The use of CBD oil suggested significant pain relief in these groups as well.
CBD isn’t yet legally cleared as an anxiolytic, or anxiety relief medication. Therefore, it’s up to you—and, ideally, a doctor who specializes in cannabis administration—to determine whether CBD is a safe treatment for your anxiety.
CBD for Generalized Anxiety.
The World Health Organization deems CBD a safe and generally well-tolerated substance. Studies report very few adverse effects, if any.
A small 2019 study of 11 patients found that, when consumed orally and administered alongside routine psychiatric care, CBD decreased patients’ posttraumatic stress disorder (PTSD) symptom severity  Elms L, Shannon S, Hughes S, Lewis N. Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. J Altern Complement Med. 2019;25(4):392-397. .
Another study involving hundreds of patients noted success with doses from 40 milligrams to 300 milligrams a day, further supporting the idea that CBD dosage varies significantly, depending on a person’s symptoms and physiology.
While tetrahydrocannabinol (THC) can have a bad rap for being psychoactive and anxiety-inducing, cannabidiol (CBD) can actually be used to relieve anxiety. Research supports this benefit, with several studies reinforcing the positive effects CBD can have on various anxiety conditions.
However, taking CBD while on other medications may pose a risk, as these substances may interact and cause unwanted effects, such as weight gain, drowsiness, upset stomach and change in appetite.