cbd experienceDecember 15, 2021
Cannabis containing 0.3 percent or less of THC is hemp. Although last year’s Farm Bill legalized hemp under federal law, it also preserved the Food and Drug Administration’s oversight of products derived from cannabis.
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Up in the wee hours of the night, stuck watching videos of puppies? CBD may be promising as a sleep aid; one of the side effects of the Epidiolex trials for epilepsy was drowsiness, according to Mr. MacKillop, a co-author of a review on cannabinoids and sleep. “If you are looking for new treatments for sleep, that may be a clue,” he said.
CBD is advertised as providing relief for anxiety, depression and post-traumatic stress disorder. It is also marketed to promote sleep. Part of CBD’s popularity is that it purports to be “nonpsychoactive,” and that consumers can reap health benefits from the plant without the high (or the midnight pizza munchies).
A few drops of CBD oil in a mocha or smoothie are not likely to do anything, researchers contend. Doctors say another force may also be at play in people feeling good: the placebo effect. That’s when someone believes a drug is working and symptoms seem to improve.
Many soldiers return home haunted by war and PTSD and often avoid certain activities, places or people associated with their traumatic events. The Department of Veterans Affairs is funding its first study on CBD, pairing it with psychotherapy.
“It’s promising in a lot of different therapeutic avenues because it’s relatively safe,” said James MacKillop, co-director of McMaster University’s Michael G. DeGroote Center for Medicinal Cannabis Research in Hamilton, Ontario.
Cannabidiol, or CBD, is the lesser-known child of the cannabis sativa plant; its more famous sibling, tetrahydrocannabinol, or THC, is the active ingredient in pot that catapults users’ “high.” With roots in Central Asia, the plant is believed to have been first used medicinally — or for rituals — around 750 B.C., though there are other estimates too.
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
However, a double-blind study found healthy volunteers administered CBD had little to no change in their emotional reaction to unpleasant images or words, compared to the placebo group. “If it’s a calming drug, it should change their responses to the stimuli,” said Harriet de Wit, co-author of the study and a professor in the University of Chicago’s department of psychiatry and behavioral neuroscience. “But it didn’t.”
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But without clinical trials in humans, psychologists say CBD’s effect on depression is still a hypothesis , and not an evidence-based treatment.
Does CBD work?
Last year, the F.D.A. approved Epidiolex, a purified CBD extract, to treat rare seizure disorders in patients 2 years or older after three randomized, double-blind and placebo-controlled clinical trials with 516 patients that showed the drug, taken along with other medications, helped to reduce seizures. These types of studies are the gold standard in medicine, in which participants are divided by chance, and neither the subject nor the investigator knows which group is taking the placebo or the medication.
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A recent chart review of 72 psychiatric patients treated with CBD found that anxiety improved, but not sleep. “Over all, we did not find that it panned out as a useful treatment for sleep,” said Dr. Scott Shannon, assistant clinical professor of psychiatry at the University of Colorado, Denver and the lead author of the review in The Permanente Journal.
This year, 1,090 people have contacted poison control centers about CBD, according to the American Association of Poison Control Centers. Over a third are estimated to have received medical attention, and 46 were admitted into a critical care unit, possibly because of exposure to other products, or drug interactions. In addition, concern over 318 animals poured into the American Society for the Prevention of Cruelty to Animals’ Animal Poison Control Center.
Dr. Smita Das, chair of the American Psychiatric Association’s Council on Addiction Psychiatry’s cannabis work group, does not recommend CBD for anxiety, PTSD, sleep or depression. With patients turning to these to unproven products, she is worried that they may delay seeking appropriate mental health care: “I’m dually concerned with how exposure to CBD products can lead somebody into continuing to cannabis products.”
Another 2019 study published in the American Journal of Psychiatry observed the effects of treating long-term heroin users with CBD. The 42 subjects were split into three groups, one had 400mg of CBD administered, the second were given 800mg and the third received a placebo. The results showed that those who used CBD experienced significantly less cravings and anxiety induced by the drug cues.
You may have heard a bit about how this cannabinoid can interact with your body’s endocannabinoid system to potentially help restore balance in a huge range of bodily functions.
Because of this, plenty of CBD users have claimed that they find CBD to be extremely effective when it comes to pain relief, when taken internally and also when applied topically, as receptors are also found in almost every skin cell throughout all lipid layers. It’s not possible to make any hard claims as to this yet though.
You may have heard anecdotes from friends about the benefits bringing this natural supplement into your life has to offer. But, while fascinating to learn about, you may feel as though none of this has clearly told you how CBD will make you feel. We’re here to fill you in.
The ECS spans the entire body. It’s considered to be one of the most important and complex networks, alongside the Central Nervous System (CNS) and Immune System. The receptors that make up the ECS have even been found within the CNS and Immune System and are now known to regulate mood, pain, inflammation, appetite, coordination among many, many other functions./p>
Is CBD addictive?
That being said, it is vitally important to be wary of poor quality, unregulated CBD products. When purchasing CBD, always look for organic growing methods and transparent lab reports to ensure you are only ever putting the very best ingredients into your body.
There is still so much to learn about CBD and this is one area that is crying out for attention – the reason for this being that the potential CBD has for those on medication could possibly be great, or not good at all.
It’s certainly a very special property of CBD products and it comes down to two things:
This is nothing to be concerned about. In fact, this sensation is mostly your own ‘bliss molecule’, the endocannabinoid called Anandamide, being allowed to flow freely as a result of CBD binding to your CB1 and CB2 receptors which then changes the shape, blocking Anandamide’s usual spot, while inhibiting the enzyme which would ordinarily break Anandamide down before it has a chance to get around. If THC is also present, this sits tightly in those receptors so there’s no chance of Anandamide settling in, making for even more of that lovely stuff swimming around your system.
So far, the World Health Organisation deems CBD as perfectly safe, without risk of dependency or abuse and full of promise for a wide range of medical uses.
Interestingly, the same goes for many people using medical marijuana for acute distress, even with higher levels of THC present. Many experts have theorised that this feeling of restored balance may come from a regulation of something dubbed an ‘endocannabinoid deficiency’ – an extremely common problem where our bodies have stopped producing and delivering appropriate amounts of Anandamide and a wide variety of other endocannabinoids, resulting in troubles with many cognitive and physiological processes, such as memory, pain, stress response, and appetite.
One week-long 2013 study published in the Addictive Behaviours journal found that participants given a CBD inhaler to use every time they felt the need to smoke reduced their number of cigarettes by 40%, while those with the placebo showed no notable difference.
This, blended with everything else CBD helps your body do, could not only make for a more enjoyable night, but a more bearable morning after too.
Cannabidiol (and cannabis, including THC and all other cannabinoids) has a fantastic safety record as a food supplement, even in high doses. Unlike many pharmaceutical medications there’s no chance of serious harm if you take a little more than you mean to. However, some studies have indicated that CBD has the ability to block a family of enzymes called cytochrome P450, which are responsible for metabolising (and therefore eliminating) 70% to 80% of pharmaceutical drugs in the liver.
How will CBD make me feel?
First and foremost, legal, professionally made CBD products in the UK will not get you high. There’s little to no THC present in CBD that is sold legally in this country – that’s the psychoactive compound commonly associated with the heady, almost drunk feeling you can get from consuming marijuana.
Mixing cannabis with alcohol is usually a no-no, as many a teenager will attest to, however, this is not the case when it comes to low THC or THC free CBD products.
One 2013 study in the journal of Pharmacology Biochemistry and Behaviour, found that CBD reduces the neurodegeneration drinking can cause, while another 2014 study published in the journal of Free Radical Biology and Medicine revealed that CBD protects the liver by inhibiting oxidative stress and increasing the destruction of damaged cells.
If enough research is done and safety measures are put into place, this could open up the possibility of patients being able to take much lower doses of their medication when used alongside CBD. But it could also indicate build up of pharmaceutical chemicals in your system, which may end being very toxic.
A huge and ever-increasing number of studies looking into cannabidiol are now (thankfully and finally!) being published on a yearly basis, and the vast majority of them are pointing towards CBD being a pretty amazing thing in almost all respects. But as this is still a relatively new science (the ECS was only discovered in the 90s after all) and widespread use of concentrated CBD is a recent thing, we are always learning.
But this little ‘rush’ isn’t the case for everyone. In fact, those with acute pain, anxiety, sleep deprivation (to name but a few) often find that all they feel is a sudden sense of equilibrium, perhaps manifested as pain reduction, a wash of soothing calm, or an energy boost.
Can I drink alcohol while taking CBD?
The most common way to start with CBD is as oil drops, taken under the tongue. Simply place 4-5 drops under the tongue and allow to absorb for 90 seconds before swallowing.
This mostly depends on what form of CBD you take (i.e. oil, capsules, vapes, edibles etc). Vaping or using cbd oil drops sublingually (under the tongue) ensures the CBD enters your bloodstream fast, and you’ll start to feel the effects within 5-10 minutes. Capsules and edibles take much longer to get to work (up to 90 minutes) and, due to having to go via your digestive system, will end up having lower bioavailability too (so you need to take much more to have the same effect). But they’re great for a slow, steady, accumulative build up.
If you’ve made it this far, you’re probably pretty curious about CBD (cannabidiol).
However, that being said, stronger doses of CBD (1,000mg+, far more than would ever normally be consumed) may make you feel ever-so-slightly light headed, briefly, as it works its way into your bloodstream and around the receptors in your body.
A number of factors are thought to cause endocannabinoid deficiency, such as lack of quality sleep, poor diet and chronic stress. CBD products simply help your body return to centre.
The impact CBD has on the human body is, given the way we are mostly all made the same inside, similar for many people. However, the dosage you take, the strain of hemp used in the product, how/where the product is grown, extraction and other ingredients included, not to mention the reason you have chosen to take CBD in the first place, all make for unique experiences.
Does it seem a little strange to you that some people use CBD to relax while others use it as a pick-me-up?