cbd for herniated disc pain

December 15, 2021 By admin Off

Research indicates that CBD may reduce back pain by:

Advocates of CBD believe it can be used to treat a range of conditions in addition to back pain, such as anxiety-related disorders. 5.

CBD is available in many forms; topical creams and gels have shown promising results for inflammation and neuropathy, which may make them a good option for back and neck pain. 2.

Cannabidiol, commonly referred to as CBD, is a new and relatively understudied treatment for pain, including back pain. Studies suggest it may help relieve inflammation, which is often a factor in chronic back pain. 1.

CBD oil is derived from a plant called cannabis sativa . The plant has over 100 chemical compounds, called cannabinoids, that have a range of effects, including anti-inflammatory and analgesic (pain relieving) qualities.

Ways CBD Treats Back Pain.

CBD requires more research in order to prove and explain its effectiveness as well as to better understand potential side effects (especially long-term) and potential drug interactions.

As with other natural products, there is potential for adverse reactions when taken with other medications, especially those that come with grapefruit warnings, such as certain blood thinners. These warnings indicate that certain medications should not be taken with products containing grapefruit.

Cannabidiol, even in high amounts, is generally safe. Side effects from CBD may include:

More severe side effects, while rare, include:

Some studies suggest that CBD can have an effect on how an individual perceives pain, but more robust research is needed. CBD is generally considered a full-body treatment, which means that it does not target back pain specifically—except in the case of topical products—but contributes to an overall feeling of relaxation and pain relief.

The cannabis sativa plant has two main varieties that are grown for specific purposes:

While CBD is present in both varieties, many of the CBD products available to consumers are from the hemp plant. CBD does not come with the high or psychogenic effects of marijuana.

Before having surgery, all cannabis use, including CBD and marijuana, should be disclosed to the surgeon or anesthesiologist. A recent study suggests that cannabis use may have an effect on medications used to sedate patients. 6.

Potential Risks and Side Effects of CBD.

What Is CBD?

The researchers wanted to see whether cannabinoids like CBD had an effect on sciatica-related pain. Prior to cannabinoid treatment, sciatic nerve tissue analysis in the animal subjects showed “marked degeneration” of myelinated fibers. In other words, damage to the rodent’s sciatic nerve was prevalent.

Back in 2005, Italian researchers conducted a study that looked at the effects of CB-1 receptors on pain response. Specifically, they observed the effects of nerve demyelination (one of the underlying causes of sciatica) in rodents. They also considered the potential influence of cannabinoid receptors on “chronic constriction injury of the sciatic nerve.”

Present findings suggest that [cannabinoid treatment] is effective not only in alleviating neuropathic pain, but also in favoring nerve myelin repair. July 2005 article from academic journal ‘Pain’

This is why CBD – and CBD oil in particular – are becoming so appealing to sufferers of sciatic pain. CBD maintains its therapeutic effect as a cannabinoid while completely bypassing psychoactive effects. In other words, it can help with pain and inflammation, but it won’t get you high.

Pain associated with the nerve can range anywhere from a mild tingling sensation in the feet or toes, to completely debilitating and immobilizing lower back and leg pain.

Current Research on CBD, Sciatica, and Potential Therapeutic Effects.

Anyone who’s suffered from sciatic nerve pain will tell you how agonizing it can be. In fact, millions of people each year resort to prescription medications to treat the often-times debilitating pain.

That said, high-quality products are still readily available in the US, with or without a medical cannabis license. These products are derived from hemp, which is a legal commercial crop under the 2018 U.S. Farm Bill.

Treatment options for sciatic nerve pain are about as far-reaching as the vast assortment of medical conditions that cause it. While some individuals may find relief through lower-back stretches and body strengthening workouts like yoga and pilates, many others are left with not much alternative other than to rely on heavy-duty prescription painkillers.

Since discovering CBD oil, Velasquez says he recovers properly and can train harder after fights. He also vows that CBD is superior to pain meds due to its non-addictive nature and minimal side effects.

The tough thing about treating slipped discs is once they become “dislodged” from beneath the vertebrae, they don’t typically heal well or go back into place on their own. Naturally, this can cause frustrating and long-term conditions. Intense pain can be a day-to-day occurrence, and sleep can become difficult. Other causes of sciatica can include:

Of course, many of us are well aware of the abuse and addiction risks (not to mention the dangerous side-effects) that come along with prescription pharmaceutical drug use .

Functionally, CBD appears to act as a ‘reinforcement’ to the body’s natural pain management system. That is, to its network of endocannabinoids and cannabinoid receptors. As a cannabinoid itself, CBD increases the number of pain modulators that are available to initiate a response to harmful stimuli. ‘Harmful stimuli’ can include anything from a bulging disc to an inflamed tissue pressing up against the sciatic nerve. In other words, it appears that CBD increases the body’s ability to minimize pain under “abnormal conditions”.

Overall, top tier CBD strains confer the ability to prevent further neurodegeneration; ideal for symptoms of sciatica. In addition, studies suggesting CBD as an essential component of neural repair and endocannabinoid synergy makes CBD the top-tier treatment for sciatica exacerbation. Dr. Mosab Deen.

The real question is how exactly does CBD and medical marijuana for sciatica work to appease the intense pain that comes along with the condition? Can it really be effective for things like pinched nerves or herniated discs?

Sciatic nerve pain can cause anything from a mild tingling sensation, to complete debilitation of the lower back and legs.

Best CBD Oil for Sciatica: Our Top Picks.

There’s a lot of misconception about what sciatica is, however. First and foremost, it is not actually a medical condition in itself; it’s a symptom of some other underlying problem. For example, a lumbar herniated disc or spinal stenosis could be the root of the problem.

This is where cannabis – and specifically CBD – comes in. The use of CBD oil for sciatica has increased to the point where some consider it an alternative option for pain management. As is the case with other conditions, more and more people are turning to it in place of prescription drugs.

Functionally, CBD acts as a ‘reinforcement’ to the body’s natural pain management system.

As it turns out, both THC and CBD (the two primary cannabinoids in marijuana), have similar effects on the Endocannabinoid System in terms of their ability to influence pain modulation.

While many things can irritate the nerve and cause acute or temporary discomfort, the most common cause of chronic sciatica is a herniated (slipped) disc. This is where the jelly-like disc protrudes from the spinal column and presses up against the nerve itself.

However, due to the obvious psychoactive effects of THC , many people are hesitant about using it as a medication. In fact, most would probably prefer not to have to get stoned in order to deal with their day-to-day pain.

All in all, many individuals who seek alternative treatment methods like CBD oil for their sciatica are chronic sufferers that want to avoid heavy-duty dosages of prescription medication.

CBD vs. THC: Are All Cannabinoids Created the Same?

Even with this promising information, it’s important to remember that CBD for sciatic nerve pain is not yet an FDA-approved form of treatment. For this reason, your doctor will not be able to prescribe it. Long-term clinical trials will be necessary if we are to get to the point where a CBD-based sciatica drug exists.

After “repeated administration” of cannabinoid treatment, it was observed that damage to the nerve tissue was reduced. This suggests that cannabinoids like CBD may be able to function in myelin tissue repair. They also may be able to “promote long-lasting functional recovery,” as noted by the researchers.

Well, you’ve basically got two options. If you live in a state where cannabis is legal (either recreationally or medically – and you have a valid MMJ card ) you can buy high-quality products from licensed marijuana dispensaries. These CBD oils are made from high-THC cannabis strains and can be very potent.

The sciatic nerve is the longest and widest nerve in the human body. It starts in the lower back and extends downwards through the buttocks and into each leg, innervating everything from the toes to the lower back muscles.

In light of the potential for CBD oil to be able to treat sciatica, you may be thinking, ‘where can I get some?’

To understand the specific physiological role of CBD in the body, we need to first understand the basic role of the endocannabinoid system as it relates to pain sensation and pain management pathways in the central nervous system.

As far as those people most at risk, individuals with overly strenuous physical labor jobs are more likely to develop sciatic nerve pain, as are individuals who sit for long periods of time (i.e. 8+ hours a day for years on end) without walking/stretching breaks.

In the event of abnormal circumstances (i.e. a herniated disc pressing up against your sciatic nerve), the endocannabinoid system becomes overwhelmed and cannot perform at its normal rate of efficiency. This is when – and why – we experience bouts of unbearable pain. It is also when the therapeutic effects of CBD may become useful.

Ethics Committee for Animal Experimentation of the University of São Paulo (CETEA, protocol n° 016/2012).

Multiple mechanisms of action have been proposed to explain CBD effects. It could antagonize the cannabinoids receptors CB1 and CB2 in low nanomolar range and to function as an inverse agonist at 1–10 µM [52]. However, to date, the presence of cannabinoids receptors has not been described in the IVD. CBD also acts as an inhibitor of anandamide uptake and hydrolysis enzymes [53], which results in enhanced levels of this endocannabinoid that might account for the anti-hyperalgesic and anti-inflammatory actions of CBD. Moreover, as a vanilloid receptor agonist with potency equivalent to capsaicin, CBD can desensitize vanilloid receptor 1 and leads to analgesic and anti-inflammatory effects [53]. The competitive inhibition of adenosine uptake and the resulting enhancement of adenosine signaling can also be involved in the anti-inflammatory effects of CBD [54].

(A) Intact disc showing well-organized fibers in the annulus fibrosus (af) with clearly defined border, and nucleus pulposus (np) comprising a significant disc area, with minimal border disruption. (B) IVD 15 days after lesion and vehicle injection showing an AF with lamellar disorganization, cavity obliteration with no NP cells and height decrease. (fm) fibrous material; sagittal sections; hematoxylin and eosin, 5X.

Funding Statement.

All animals were submitted to MRI two days after the IVD puncture and CBD (30, 60 or 120 nmol) microinjection. Animals that received CBD 120 nmol microinjection were resubmitted to MRI at the 15 th day post-lesion and then to the histological analyses.

The purpose of this study was to evaluate by magnetic resonance imaging (MRI) and histological analysis the effects of intradiscal injection of CBD in an induced coccygeal disc degeneration model.

Cannabidiol (CBD) is the major nonpsychotropic phytocannabinoid of Cannabis sativa (up to 40% of Cannabis extracts). Contrary to most cannabinoids, CBD does not produce psychotomimetic or cognitive effects [15], [16]. Interesting, in the last years it has been suggest that CBD produces a plethora of others pharmacological effects, including antioxidant [17], neuroprotective [18], [19], [20], [21], [22], anti-proliferative [23], [24], anti-anxiety [25], [26], hypnotic and antiepileptic [27], anti-nausea [28], anti-ischemic [29], anti-hyperalgesic [30], and anti-inflammatory [31], [32], [33]. In humans, CBD has been tested in preliminary trials related to diseases such as rheumatoid arthritis [34], [35], multiple sclerosis [36], [37], [38], anxiety [16] and psychosis [39], and shows an extremely safe profile [40], [41]. However, the effects of CBD on the treatment of IVD degeneration have not been investigated yet.

The primary objective of this study was to investigate the ability of CBD to decrease degenerative events induced by needle puncture of the IVD. Three concentrations of CBD were injected into the IVDs immediately after the disc puncture.

Histological features of the degenerating IVD include specific changes of the NP and AF [43], [49], [50]. The NP shows severe disruption and a gradual decrease in cell number, with reduction in its cavity until complete obliteration. This is consistent with the loss of proteoglycan seen in degenerative models [43], [49], [50] and in human degenerated discs [51]. The AF had radial gaps between lamellae with fragmentation culminating in regions of disorganized fibrous material replacing central lamellae [43], [49], [50]. CBD treatment was able to attenuate the decrease in histological scores induced by the lesion in the AF, but not in the NP region. This lack of correlation between the MRI and histological analysis in the latter region suggest, at least in the present model, a higher sensitivity of the former method.

Treatment with CBD 30 or 60 nmol immediately after lesion did not modify MRI pixel intensity ( Fig. 4A and B ). Microinjection of CBD 120 nmol immediately after lesion significantly improved MRI pixel intensity two days after the injection compared to the vehicle injected lesioned discs ( Fig. 4C ).

Injection of CBD 120 nmol immediately after lesion significantly improved MRI pixel intensity. The effect was maintained at least for 15 days after injection compared to the vehicle injected lesioned discs ( Fig. 5 ).

We would like to thank Célia Ap. da Silva for the technical support and to João Francisco Cordeiro Pedrazzi for his helpful assistance with cannabidiol.

Long-term effects of intradiscal injection of cannabidiol (120 nmol)

IVDs that received an injection of vehicle after needle puncture showed significant worse histological scores. CBD 120 nmol injection significantly improved histological scores of the AF. *p<0.05 versus intact discs. # p<0.05 versus vehicle injected lesioned discs.

The animals were divided into three sub-groups (with 6–7 animals each) according to CBD doses ( Fig. 1 ). Under general anesthesia, immediately after the disc puncture, 2 µl of CBD (30, 60 or 120 nmol) diluted in 98% saline and 2% Tweem-80 was injected into the Co6–7 lesioned discs. Likewise, the lesioned discs Co8–9 and the non-lesioned discs Co9–10 were injected with vehicle (saline + Tweem-80; 2 µl). Both CBD and vehicle injections were conducted using a Hamilton micro-syringe attached to a 30-gauge needle.

The injection of CBD 30 (A) or 60 nmol (B) did not prevent the MRI signal reduction induced by needle puncture. CBD 120 nmol injected into the punctured discs mitigates the MRI changes (C). The injection of vehicle per se caused significant changes in the MRI signal intensity of the non-puncture discs compared to the intact discs (A–C). *p<0.05 versus intact discs. # p<0.05 versus vehicle injected lesioned discs.

In summary our study revealed anti-degenerative effects of intradiscal microinjection of CBD 120 nmol. CBD represents one of the most promising candidates present in the Cannabis sativa plant for clinical use due to its remarkable lack of cognitive or psychotomimetic actions. It has been already approved in several countries for the treatment of neuropathic pain [63]. Although further research is necessary to clarify the mechanisms involved in CBD effects, the present results suggest the possibility of its use for disc degeneration treatment.

Animals were sacrificed by CO 2 inhalation 15 days after the disc puncture. IVDs were removed, fixed in buffered 4% PFA for 24 hours and then subjected to the decalcification process in an ETDA solution consisting of 12% hydrochloric acid, 0.07% EDTA, 0.014% sodium tartrate, 0.8% sodium and potassium tartrate, in water, during 24 hours. After descaling, IVDs were dehydrated, embedded in paraffin and 5 µm sections were obtained with a microtome (Leica RM2145). The sections were then stained with hematoxylin and eosin for histological score and graded by an observer blind to the treatment conditions using the definition established by Norcross et al. 2003 [43], with some modifications ( Table 1 ), under a light microscope (Leica, Germany) at 5× magnification. A grade score ranged from 1 (several degenerated disc) to 5 (normal disc) was assigned separately to both AF and NP.

Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have not been investigated yet. The present study investigated the effects of cannabidiol intradiscal injection in the coccygeal intervertebral disc degeneration induced by the needle puncture model using magnetic resonance imaging (MRI) and histological analyses. Disc injury was induced in the tail of male Wistar rats via a single needle puncture. The discs selected for injury were punctured percutaneously using a 21-gauge needle. MRI and histological evaluation were employed to assess the results. The effects of intradiscal injection of cannabidiol (30, 60 or 120 nmol) injected immediately after lesion were analyzed acutely (2 days) by MRI. The experimental group that received cannabidiol 120 nmol was resubmitted to MRI examination and then to histological analyses 15 days after lesion/cannabidiol injection. The needle puncture produced a significant disc injury detected both by MRI and histological analyses. Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture. Considering that cannabidiol presents an extremely safe profile and is currently being used clinically, these results suggest that this compound could be useful in the treatment of intervertebral disc degeneration.

MRI acquisition.

MRI data was corroborated by histological results. The histological score was evaluated at fifteen days after the lesion and injection of vehicle or CBD 120. The lesion decreased the histological scores in the AF and NP. CBD 120 nmol prevented the typical histological changes in the AF. No histological changes were observed when the vehicle was injected into the intact disc ( Fig. 6 ).

Fig. 2 shows the typical morphology of the intact IVD, which presents an AF with well-organized fibers and a clearly defined border. The NP comprises a significant disc area in the sagittal sections with minimal disruption in its border. Clear histological changes can be observed in the IVD after lesion with the needle puncture. Disc sections showed an AF with lamellar disorganization/fragmentation. NP presented complete obliteration of its cavity with fibrous material. Also, there is a significant decrease of the IVD height.

The IVD is identified as an immune-privileged organ with no access to systemic circulation [3]. However, several pieces of evidence support the prominence of the inflammatory response in the pathogenesis of IVD degeneration [4], [5], [6]. In fact, there is an up-regulation of inflammatory factors that shift homeostasis of the extracellular matrix towards a degenerative and catabolic state, with subsequent breakdown of its components [7], [8]. On the other hand, there is conflicting information regarding the efficacy of intradiscal steroid injections in the treatment of IVD [9], [10], [11], [12]. A clinical study conducted by Buttermman (2004) [13] suggested that intradiscal steroid injections are beneficial for a small number of patients with advanced IVD degeneration. This therapeutic strategy could be more effective in special circumstances in which patients have inflammatory end-plate alterations classified as Modic Type I changes [13], [14].

The injection of CBD 120 nmol into the punctured discs mitigates the MRI changes. The injection of vehicle per se caused significant changes in the MRI signal intensity of the non-puncture discs compared to the intact discs. *p<0.05 versus intact discs. # p<0.05 versus vehicle injected lesioned discs.

This research was supported by CAPES/PNPD, Brazil. The equipment and drugs used in this work were acquired from FAPESP, CNPq, and CAPES, Brazil. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Considering that the modulation of immune responses in the degenerate disc is essential for the recovery of this immune-privileged organ [3], [55], the effects of CBD in lesion-induced degeneration could depend on its anti-inflammatory profile. Disc degeneration involves the release of many inflammatory signaling molecules [31], [56], [4], [5], [6]. In most models of inflammation, CBD attenuates inflammatory cell migration/infiltration [57], [33] and the production of inflammatory mediators [58]. For example, CBD suppresses proinflammatory signaling, including NF-κB, induced by LPS [56]. Time- and dose-dependent anti-inflammatory activity has also been observed in acute inflammation models [31]. CBD is also effective in chronic neuropathic painful states that are associated with the release of proinflammatory cytokines, such as IL-6, IL-1β, and TNFα [20], [33], [56]. Moreover, CBD can abolish the increase of nitric oxide levels in paw tissues in inflammatory and neuropathic pain models [59]. Finally, the ability of CBD to reduce inflammatory markers has been shown in several experimental different conditions. CBD treatment inhibits the progression of periodontitis that was accompanied by a decrease in neutrophil migration, expression of bone related molecules and production of IL-1β and TNF-α [33]. In arthritis models, CBD blocks its progression, decreasing collagen II-specific proliferation and IFN-γ production, as well as decreasing the release of TNF-α by synovial cells [35]. In diabetic retina, the increase in phosphorylation of p38 MAP kinase, a stress-activated protein kinase that is a downstream target of proinflammatory cytokines, is blocked by CBD treatment [60]. Additionally, CBD beneficial effects have been recently described in the liver injury model of hepatic ischemia/reperfusion by attenuating inflammatory signaling in a CB1/2 receptors independent manner [61], [62].

The MR images of the NP in the punctured discs showed weaker signal intensities than those of the intact control discs two days after needle puncture. In the NP, decreased water, proteoglycans and increased collagen content are classical technical features of degenerated IVD, which can be visualized on MRI with T2 weighting as a hypointense signal. Representative serial T2-weighted midsagittal images of the intact and punctured tail discs are shown in Fig. 3 .