cbd oil down syndrome

December 15, 2021 By admin Off

Furthermore, people with Down syndrome often suffer from gastrointestinal symptoms such as vomiting, diarrhea, abdominal pain, and constipation, and have an increased risk of developing GI disorders. There’s evidence that cannabis can be helpful here as well. For one, a 2015 review of 23 clinical studies concluded that cannabis-based medicines may relieve nausea and vomiting caused by chemotherapy.

There’s also research evidence that cannabis can relieve some symptoms that occur in this condition, such as impulsivity, digestive issues, and seizures. Cannabis may also be able to help by protecting people with Down syndrome from amyloid plaques, which has been linked to the cognitive deficits which also occur in those suffering from Alzheimer’s disease.

Furthermore, there’s some evidence that the non-psychoactive cannabinoid CBD may help with poor sleep. For example, a 2019 study found that CBD improved sleep issues in 67% of the 72 study participants.

There’s also evidence that cannabis may help relieve other GI symptoms. One 2011 study of people with inflammatory bowel diseases (IBD) found that cannabis was commonly used to relieve symptoms of abdominal pain, diarrhea, and bloating . Similar results were reported by a 2019 study . Additionally, the pain-relieving effects of cannabinoids are supported by a large body of evidence.

Although cannabis shows early promise in the treatment of Down syndrome, it does have some side effects. These tend to vary depending on whether you’re using a THC- or CBD-heavy preparation.

Medical studies on Down syndrome and cannabis.

Recent studies suggest that the potential benefits of cannabis-based products in Down syndrome symptoms are due to the involvement of the body’s endocannabinoid system in the disorder. Most notably, researchers have found that people with Down syndrome have excessive endocannabinoid receptor activity in the hippocampus, the part of the brain associated with memory and that blocking this overstimulation may provide cognitive benefits.

Regular, THC-rich cannabis (commonly known as marijuana) can cause dry mouth, red eyes, sleepiness, dizziness, impaired memory and reaction time, and increased heart rate. Some individuals might also experience feelings of paranoia and anxiety.

CBD can also help with the seizures that occur in about 8% of people with Down syndrome . In fact, CBD has been shown to be an effective seizure treatment and CBD-based drug Epidiolex received FDA approval for treating specific seizure conditions including Dravet Syndrome and Lennox-Gastaut in 2018. The research in this area is quite promising, suggesting that CBD may treat a variety of seizures:

For starters, studies show that cannabis may help with some Down symptoms, including impulsivity, inattention, gastrointestinal issues, sleeping problems, and seizures.

Although more human-based studies are sorely needed, current findings highlight the potential of cannabis-based medicines in DS. Here’s what the research says.

The endocannabinoid system (ECS) exists in all vertebrates and helps regulate crucial functions such as sleep, pain, and appetite. The human body produces its own cannabinoids, which modulate and activate its various functions, but as its name suggests, the endocannabinoid system can also be modulated and activated by cannabinoids found in the cannabis plant. Because the entire system was only discovered in the past 30 years, scientists still have much to learn about the myriad ways cannabis affects the human body.

A 2019 animal study also made several connections between CB1 receptors and Down syndrome . The researchers examined two mouse models, discovering the following:

One 2017 clinical study found that cannabis-based medication Sativex improved hyperactivity, impulsivity, and other symptoms in people with ADHD. Since difficulty focusing and impulsive behavior is a common issue for children with Down syndrome, this is quite significant.

These findings do not make it clear whether the ECS is actually dysfunctional in Down syndrome or simply acting as a defense mechanism. However, they do suggest that therapies that target the ECS — including cannabis — could potentially improve some symptoms.

How cannabis works on Down Syndrome.

Lastly, there’s anecdotal evidence that hemp-based (low THC/high CBD) preparations such as CBD oil may improve Down symptoms . In particular, parents of children with Down syndrome have reported improvements in speech (being able to speak more clearly and in longer sentences), attention and focus, mobility (improved ability to walk and play/exercise), and seizures.

Yet another way that cannabis can help with Down syndrome is by protecting the brain against beta-amyloid plaques and neurodegeneration . These plaques may play a role in the cognitive deficits seen during development and aging in people with Down syndromes. The neuroprotective effects of cannabinoids have been demonstrated in several studies:

This all amounts to a patchwork of evidence that cannabis-based medicines can help children and adults with Down syndrome by improving some symptoms and protecting against amyloid plaques and neurodegeneration. However, it’s too early to say anything more substantial. More research is needed, particularly human studies of cannabis-based medicines in people with Down syndrome.

For starters, a 2008 study that examined Down syndrome brain tissue found a link between beta-amyloid plaques and the ECS. The brain cells associated with these plaques had increased activity of CB2 receptors and the enzyme FAAH, which breaks down the endocannabinoid anandamide.

In recent years, parents have reported improvement in children with Down syndrome’s inattention, speech problems, and other symptoms after using CBD oil.

Meanwhile, a 2014 animal study found that blocking MAGL, an enzyme that breaks down the endocannabinoid 2-AG, reduced beta-amyloid levels, and improved long-term memory and some other cognitive deficits in mice with Down syndrome .

Potential side effects of cannabis use.

There have been no animal or human studies looking at the use of cannabis for Down syndrome. However, there is still evidence that cannabis-based products can improve some symptoms and protect the brain against amyloid plaques that may contribute to cognitive issues in both Alzheimer’s disease and Down syndrome.

Meanwhile, CBD-rich preparations (especially those made from hemp), such as CBD oil, have too little THC to cause mind-altering effects. They can cause minor side effects including diarrhea, low blood pressure, dry mouth, lightheadedness, sleepiness, and changes in appetite. However, these effects are unlikely to occur at the doses taken by most people and have only been reported in studies using extremely high doses .

The ECS plays an essential role in cognitive health and function , particularly through the activity of the cannabinoid type-1 (CB1) receptor, which is abundant in the brain. ECS dysfunction has been linked to depression and other neurological disorders, and recent research suggests that the ECS may be also involved in Down syndrome.

Overall, although cannabis is a relatively safe option with temporary side effects, it’s always best to consult with a healthcare professional before starting treatment.

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He hopes he will be able to fundraise the cash to pay for treatment.

Thomas Cotter, 47, says he has watched 10-year-old Elliot deteriorate in front of his eyes after the schoolboy began suffering seizures in 2017.

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Thomas has been unable to work after becoming the youngster's full-time carer when Elliot’s mum died from lung cancer in 2015.

"When he has a seizure there's no warning, he just drops to the floor like someone has shot him. It just seems to be getting worse and worse.

Thomas Cotter, 47, says he has watched 10-year-old Elliot deteriorate in front of his eyes after the schoolboy began suffering seizures in 2017.

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He added: "I’ve read stories of parents that have given medical cannabis to their kids in real cases where it has worked and it gives me hope."

“He’s totally depressed. He doesn’t talk but I can tell how fed up he is.

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"He was always a happy wee boy, he was a ray of sunshine, laughing and having a carry-on and loved school. He was like a koala, always holding on and all the teachers adored him.

"We manage his seizures at home and we've been lucky that he's not needed to be hospitalised because of them yet.

"All he’s doing is sleeping and getting up and having a seizure. It’s affecting him a lot more now than even a month ago.

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Four years on Thomas says his son’s condition has spiralled out of control with the youngster, who is also autistic and non-verbal, being forced to take 10 pills every day to control the fits.

"They used to mainly happen in the morning and night but it’s started to spiral out of control and can happen any time."

"It’s soul-destroying, it’s just so difficult. There’s a lot of tears behind closed doors when you see your boy suffer.

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Autism is a spectrum disorder to complicate issues. Symptoms of different patients vary, and the treatment that works for one individual will not necessarily work for another. However, several specialists currently believe that autism could be caused by a hereditary change that leads to chronically little levels of natural endocannabinoids in the mind. It also disturbs the normal way someone’s mind connects with these chemicals.

Autism is more common than Down Syndrome and affects about 1 of 100 children. Even though many people with autism tend to be incredibly intelligent, they are usually kept down by their failure to connect with other people or keep up with social standards. Hence, both grown-ups and youngsters with autism are prone to encountering levels of antagonistic vibe or anxiety hard to live with. This makes them push others away end up in a circle of social isolation.

Post-modern examinations show that cerebrums donated by people with Down syndrome have plaques similar to those of Alzheimer’s. The plaques are believed to be identified with high levels of unsaturated fatty acid amide hydrolase (FAAH) and excessive amounts of CB2 receptors.

Since CBD and THC in cannabis have a comparative structure with body-created cannabinoids, supplementation may help. Actually, the Autism Research Institute has officially given people with mental imbalance small safe doses of cannabis in a controlled setting. In many of the study participants, tension, self-destructive behavior, and antagonistic vibe reduced.

For every 700 to 1,000 people, at least one has Down syndrome. The hypothesis is that people with Down syndrome have a massive number of CB1 receptors in their hippocampus, and are overreactive. In turn, this harms the interfacing neurons and prompts cognitive impairment. To validate their hypothesis, researchers tried the memory of mice with the Down syndrome version of mice before and after down-managing their CB1 activity. Memory improvements were observed after treatment.

The Relationship Between Cannabis and Down Syndrome.

Scientists are currently investigating how the all-natural treatment by cannabis can improve the quality of life for persons with all sorts of disabilities such as down syndrome, chemical imbalance and cerebral paralysis, among others. Here is what the science researchers are looking for:

Like any other human, persons with disabilities to have an endocannabinoid system. Cannabis has, over time, had great benefits to kids with intractable epilepsy, when no other treatment worked.

This Dad gave the kid concentrated THCA two times daily. This kind of THC does not make the user high. The outcomes were shockingly positive, and the boy not only became calmer but also did he gain more joy.

Abnormal FAAH amounts propose a chronically-starved endocannabinoid system. Hence, supplementation with low cannabis portions are likely to keep CB1, and CB2 receptors occupied, break down plaques in the brain, ensure neurons, and reduce excess FAAH amounts.

According to some anecdotes, improvement is not on the grounds that these patients just became high and mellowed out. In 2008, a father to an autistic child in California publicly opened up about how he effectively treated the mood swings and anger of his child with crude cannabis after innumerable pharmaceuticals failed to help.

Nevertheless, more research, especially in human subjects, is needed.

Charnell Lock lives in sunny San Diego but is originally from North Carolina and has been writing professionally since 2011. After four years with the Navy and an Associate’s Degree in Liberal Arts, Charnell found her passion in creating diverse content with well-formatted research. Along with her years in active duty service, she is capable of crafting whimsical short stories to medical-oriented papers as her capacity to contribute here is immense and will be a staple for many years to come.

The Effect Of Cannabis on Autism.