cbd reduces function in immune systemDecember 15, 2021
Compounds that stimulate the ECS could reduce nerve cell degeneration.
Also, the FDA does not yet recognize CBD as a medicine. This means CBD sellers are legally obliged to market their CBD tinctures as “nutritional supplements” rather than actual medicinal drugs.
Bear in mind, however, that as of right now, all of this research is still speculative. We require far more in-depth studies to have a more thorough understanding of the exact molecular pathways at work.
Experts believe that CBD could protect nerve cells because of its efficacy as an antioxidant. Few people know that the U.S. government holds a patent on cannabinoids for this exact purpose.
To even scratch the surface in describing CBD’s potential effects on the body’s immune system, we need a basic understanding of how the endocannabinoid system works.
Does CBD Benefit the Immune System?
The endocannabinoid system, or ECS, is a network of cannabinoids and receptors that regulate most functions in the human body . As researchers have described it, one of these functions is its role as an “immuno-cannabinoid” modulator.
Among other things, these “instructions” provide information for the body’s immune system that tells it when to engage its line of defense, where, and how strongly to engage it.
Whenever possible, however, try to speak with a physician or other clinical professional regarding the use of CBD oil for immune health. We have recently published an article relating to specific CBD dosing guidelines . However, we must reiterate the fact that we are not health professionals. Therefore, none of the information on this site should be interpreted as clinical advice.
We know that patients who suffer from autoimmune conditions, like rheumatoid arthritis, frequently use cannabis as adjuvant therapy. But is it useful for healthy individuals? Could it potentially prevent diseases and boost overall immune health?
Additionally, some researchers have even speculated that the ECS may work to “notify” the body of an “incorrect” autoimmune response, wherein the defense cells attack otherwise healthy organs and tissues. This may be why cannabinoids seem to function so well in treating autoimmune conditions like multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, etc.
Not even the world’s leading medical cannabis experts can outwardly claim that CBD has a “such-and-such” effect on the immune system. It’s clear (according to several studies) that cannabinoids have some influence on the overall immune response. However, it’s unclear how we might manipulate it or administer treatments to achieve the most beneficial results possible.
This means that “communicative” molecules in the ECS can work as a signaling mechanism. They provide instructions for the functional machinery involved in the immune response.
Over the last few decades, int…
Are you considering taking CBD for immune system health or an autoimmune condition that you already have? If so, please note that there are dozens of high-quality CBD oils and tinctures available for sale online. Most companies can ship to all 50 U.S. states due to their manufacturing guidelines under the 2018 Farm Bill.
CBD and the Immune System: Have We Even Scratched the Surface?
This article explores some of the most relevant research publications on CBD’s far-reaching influence on the immune system. A greater clinical foundation is necessary to come to any definitive conclusions regarding its specific physiological effects. However, it’s clear that the endocannabinoid system and the immune system are very interrelated.
So, what does this mean? When an individual suffers a serious traumatic event (i.e., has a severe head injury, stroke, etc.), the lack of oxygen and excess inflammation severely damages the nerve cells.
Moreover, we know that compounds that stimulate the endocannabinoid system can promote new nerve cell generation (neurogenesis). They could also reduce nerve cell degeneration (this last part was already seen in animals).
While cannabinoids impact the immune response, experts are not yet sure how to use them effectively.
Let’s make one thing very clear: there is much about the functioning of the immune system and the body’s immune response that is unknown. Even less is known about the body’s endocannabinoid system.
The term “immune health” is incredibly broad in the medical world, and it can invoke several different clinical interpretations. Several scientific publications have described the “immunomodulating” properties of active cannabinoids (like CBD) – but what does this mean, exactly?
CBD and the Immune System: Bridged by the Endocannabinoid System.
However, we know that cannabinoids such as CBD can reduce painful, inflammatory responses in humans when taken at certain levels. This is particularly true among those who suffer from some of the aforementioned autoimmune conditions.
One thing worth researching more, however, is CBD’s potential ability to “balance” the two major arms of the immune system.
Generally speaking, there are two different ways in which the body’s adaptive immune cells can seek out and “eliminate” dangerous pathogens (foreign agents that can result in disease, infection, etc.):
In autoimmune diseases, one of these types of immunity becomes overactive and begins to attack and destroy healthy cells and tissues.
And finally, make sure you perform thorough research on your own and use CBD under your judgment. We make no outward claims or guarantees that it will be effective or therapeutic for you and your condition, regardless of data that’s available in scientific studies.
The Science Behind CBD Strengthening the Immune System.
Several studies have been undertaken into the affect CBD has on humans suffering from autoimmune diseases. However, there has been no resulting guidance from these studies to suggest a specific dose recommended for a particular disorder linked to the immune system.
CBD helps to boost immunity by working in conjunction with the endocannabinoid system works. The therapeutic effects of CBD come to fruition via their interaction with the body’s endocannabinoid system and the specific cannabinoid receptors. The endocannabinoid system is integral to the body’s physiologies and regulates a variety of bodily functions. These functions include pain, immune response, sleep, mood, memory, anxiety and appetite. The interaction with cannabinoid receptors enables anandamide to function. Anandamide is responsible for regulating appetite and stress responses in the body.
Possible Cons/Side Effects of CBD.
CBD and inflammation.
Cannabis and its derivatives are known to be immune modulating meaning that it can regulate over and under reacting immune systems back into balance.
CBD interacts with other receptors in the body such as 5-HT1A which is related to serotonin, which is a neurotransmitter found to be a contributor to feelings of well-being. It is through this interaction that healing and balance is promoted by the cannabinoids.
The dysfunction of the immune system and it not performing optimally is one of the causes of HIV/AIDS. HIV compromises the immune system, due to which the body leaves its ability to fight the virus. As CBD has the ability to make the immune system perform better, it tends to be a good option in relieving HIV symptoms. A study conducted in 2015 found that the patients who consumed CBD had less viral loads and a more CD4 immune cell which fights against HIV as compared to regular patients. Another previous study of 2003 revealed that the through the use of CBD the T-cell count can be increased, t-cells are used to destroy harmful pathogens and are integral need of the immune system. Moreover, recent studies show that CBD may also be helpful in inhibiting the progression of HIV into AIDS by inhibiting the function of plasmacytoid dendritic cells.
Living a healthy lifestyle and consuming a balanced diet are great ways to ensure your immune system is strong. The immune system works best when it is not subject to environmental factors and way to boost your immune system are;
The immune system also has a major role in neuroinflammatory and neurodegenerative conditions like strokes, head injuries and cerebral ischemia which is a condition in which there is an insufficient flow of blood to the brain. CBD has been used to provide both neurogenesis as well as neurodegeneration which leads to the promotion of new and degeneration of nervous tissues of the brain. The research that concluded these findings was however conducted on animals, more evidence is needed in order to prove the significant effects.
The precise nature in which cannabinoids elicit the reaction to kill cancer cells is still being researched. There is still a tremendous amount of studies and research that needs to take place to garner a stronger understanding of how this process happens and how it can be optimised for humanity’s benefit. Being aware that CBD oil could be able to inhibit potentially lethal cancerous cells when the immune system is unable to inhibit the cancerous cells is extremely encouraging and could be the precipice of new revolutionary medicines.
Final thoughts on CBD and the Immune System.
A weakened immune system leads to cancer, and CBD is also able to fight cancer by strengthening the immune system. One of the functions of the immune system is to tell the unhealthy and aged cells about their time to self-destruct. As with cancer, the damaged cells forget their ability to self-regulate and the disease spread quickly in the body due to the proliferation of the cells. Animal and laboratory studies show that CBD help in the self-destruction of the damaged cells, which lead to apoptosis, and eventually a reduction of the tumour growth. Metastasis was also a result of the mice study that reduced the spreading of cancerous cells. Thus, the immune system is strengthened and it also reduces nausea, vomiting and various conditions caused by chemotherapy in the cancer patients.
Inflammation, besides its negative aspects, is vital for the immune system to inhibit infections. Inflammation is the immune response required to stop the diseases from spreading by isolating the damaged and infected cells. Therefore, inflammation is needed to fight certain diseases in the body and preventing it can weaken the immune system. However, CBD can also be used to maintain a balance between the functions of the immune system.
New data that was published in Cannabis and Cannabinoid Research in 2020 supports the idea that CBD is an immunosuppressive, meaning it helps to suppress the immune response. Cannabis is known to be immune modulating, meaning that Cannabis can regulate an over or under reacting immune system back into balance. However, there is still a tremendous amount of research that needs to be done to understand the difference between CBD’s immune boosting and immune modulating characteristics. More expansive studies need to be undertaken to gain a definitive understanding of the full impact CBD has on the immune system.
One of the very few examples of there being definitive dosage guidance pertains to the drug Epidiolex for epilepsy in children. The doses can be as high as 20mg/kg but doses as high as 300mg/kg have been evaluated and have not exhibited significant adverse effects. Autoimmune conditions are often the potential cause of seizures.
CBD has numerous anti-inflammatory effects on the central nervous system that enable it to have therapeutic effects.
Many of the studies that have been undertaken concerning CBD are too limited to ascertain whether CBD is definitively an effective treatment except in cases like Epidiolex which has been approved by NICE and is available on prescription.