cbd sertraline

December 15, 2021 By admin Off

There’s no denying that CBD, aka cannabidiol, has been the reigning trend of the last few years, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic, and safe way to manage a variety of health issues, you may be wondering if you can take CBD and antidepressants together. And while CBD is touted as an all-natural supplement with some evidence that it can be good for your health, it’s possible that your CBD latte can still impact the efficacy of different medications — including antidepressants.

The reason for this is that CBD inhibits two main enzyme systems, Grinspoon explains. Enzymes are proteins that speed up chemical reactions in the body, and play an important role in functions like digestion and respiration. They also help you metabolize antidepressants. “One system is the same one that grapefruit inhibits — the technical name is the CYP34A enzyme system. So, just like grapefruit juice, CBD can cause your body to have higher doses of benzodiazepines [anti-anxiety medications], or certain antipsychotic medications,” Grinspon explains.

The 2018 passing of the bipartisan Farm Bill legalized the production of hemp on an industrial scale for the first time in the U.S. — which means it’s that the CBD industry will only continue to grow. However, this doesn’t necessarily mean there will be more oversight or required research.

What’s more, Grinspoon says that CBD also inhibits “the system that metabolizes a lot of serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and antipsychotics as well.” Meaning, taking CBD supplements while on these psychiatric medications could hypothetically interfere with how these medications are metabolized.

“Generally speaking, you can safely use CBD supplements when you’re taking antidepressants. However, there are a couple of concerns,” Dr. Peter Grinspoon, M.D., an instructor in medicine at Harvard Medical School, and the author of the memoir Free Refills: A Doctor Confronts His Addiction , tells Bustle. “The first concern is that CBD isn’t regulated by the FDA. You have to be careful that the CBD you’re getting is from a reliable supplier. For example, Consumer Reports recently put out an article on how to go shopping for CBD because they’ve done tests, and found some [supplement] formulations had no CBD. Some were inaccurately labeled, and other formulations even had some THC in them.” (THC is the cannabis compound that, unlike CBD, can get you high.)

So, what can potentially happen if you take CBD oil and antidepressants? Unfortunately, because there’s a limited amount of studies to draw from, Grinspoon says, “CBD does have hypothetical drug interactions; the question is whether these are clinically important or not.”

Dr. Peter Grinspoon, M.D., author and instructor in medicine at Harvard Medical School.

According to statistics from the National Alliance on Mental Illness (NAMI), one in five U.S. adults live with a mental illness in any given year. Furthermore, as NBC News reported, a 2016 study revealed one in six people in the U.S. take some type of psychiatric medication, with antidepressants being the most widely prescribed. Limited research has shown that CBD may help alleviate symptoms of anxiety and sleep issues, as well as lower levels of inflammation in the body, though this research (and the dosages needed for these effects) is nowhere near conclusive. And that means you need to be careful if you’re choosing to consume it.

Despite this, Grinspoon explains that this is typically not a large cause of concern for a majority of people on antidepressants or other psychiatric medications. “Certainly, if someone is on a very delicately balanced medical regiment, CBD could knock that out of whack because of the two different enzyme systems it inhibits. In terms of actual clinical practice, I haven’t heard any stories of people having clinical decompensation because of adding CBD to their regime,” he says.

Readers should note that the regulations and data surrounding marijuana, CBD, and other related products are still developing. As such, the information contained in this post should not be construed as medical or legal advice. Always consult with your doctor before trying any substance or supplement.

When it comes down to it, Grinspoon says that the potential interactions should be regarded as more “hypothetical than real,” and that the side effect profile of CBD is “very minimal.” Of course, it’s always good to have a conversation with your physician about potential interactions, and to disclose any prescribed or over-the-counter medications and supplements you are taking. At the end of the day, using CBD supplements while on antidepressants is an individual choice, but it’s important to go in informed.

Moore TJ, Mattison DR. Adult Utilization of Psychiatric Drugs and Differences by Sex, Age, and Race. JAMA Intern Med. 2017;177(2):274–275. doi:10.1001/jamainternmed.2016.7507.

Sertraline is known as a “selective serotonin reuptake inhibitor” or (SSRI ) and works by restoring the balance of serotonin in the brain.

So with that in mind, it’s best to understand more about how CBD could interact with sertraline. Let’s tackle that next.

Moreover, as of now, no study has provided evidence that CBD can be used specifically to replace sertraline.

What is CBD.

Before beginning with this topic, it’s important to get a breakdown of what these two components are.

CBD is also used for treating conditions such as anxiety, insomnia, and a variety of chronic pain. But it can cause side effects such as headaches.

The studies we know of that we can fall back on help us answer whether you can take CBD with sertraline.

In another study published in Frontiers in Neuroscience, also in 2018, it was stated that CBD might help treat a variety of psychological conditions. Such conditions include mental health and post-traumatic stress disorder (PTSD) – the same conditions for which sertraline is commonly prescribed.

In contrast to this process, research indicates that CBD inhibits many of the metabolizing enzymes listed above. This increases the risk of adverse effects as a result of increasing sertraline concentration in the body.

To back this up, a study published in the British Journal of Pharmacology found that CBD induced fast and sustained antidepressant-like effects in animal models comparable to those of imipramine. Imipramine is a tricyclic antidepressant (TCA) used mainly for the treatment of depression.

How can CBD interact with sertraline?

It’s believed that using CBD with sertraline is likely to worsen the side effects of sertraline.

It is used for treating a variety of conditions starting from, but not limited to:

The outcome for CBD and sertraline is not that promising, so do not stop taking your medication at this point. Proceed with caution and consult your doctor before taking these elements together.

Moreover, it can reduce your urge to perform repeated tasks that disturb your daily routine.

Dependent on brain serotonin.

A solid answer to whether you can take CBD with sertraline is still largely unknown because of unstudied potential interactions.

In general, it’s believed that CBD does have some theoretical drug interactions. However, many believe that the interactions are only mild or rare and would not bring about any severe reactions. However, there is not enough clinical evidence to say for sure.

Sertraline is an antidepressant sold under the brand name Zoloft .

The metabolization of any medications is essential to get rid of the pharmaceutical compounds from the body.

Firstly, additional data on CBD interaction states that the risk of CBD interacting with sertraline is specifically is low.

This study evaluated the effects of cannabidiol (CBD) and/or sertraline (STR) on behavioral and gene expression alterations induced by a new chronic animal model of post-traumatic stress disorder (PTSD). C57BL/6J male mice were repeatedly exposed to physical and psychogenic alternate stressful stimuli. Fear-related memory and anxiety-like behaviors were evaluated. The effects of the administration of CBD (20 mg/kg, i.p.) and/or STR (10 mg/kg, p.o.) were analyzed on behavioral and gene expression changes induced by the model of PTSD. Gene expression alterations of targets related with stress regulation, endocannabinoid and serotonergic systems were analyzed by real-time PCR. The results revealed an increased and long-lasting fear-related memory and anxiety-like behaviors in mice exposed to the animal model of PTSD. Treatment with CBD improved these behaviors in PTSD animals, effects that were significantly potentiated when combined with STR. Gene expression analyses revealed a long-term increase of corticotropin releasing factor ( Crf ) that was significantly normalized with the combination CBD plus STR. Cannabinoid receptors ( Cnr1 and Cnr2 ) were up regulated in PTSD mice whereas the serotonin transporter ( Slc6a4 ) was reduced. Interestingly, CBD and STR alone or combined induced a significant and marked increase of Slc6a4 gene expression. These results point out the cooperative action of the combination CBD plus STR to enhance fear extinction and reduce anxiety-like behaviors, normalizing gene expression alterations in this animal model of PTSD and suggesting that the combination of CBD with STR deserves to be further explored for the treatment of patients with PTSD.

Copyright © 2021 Gasparyan, Navarrete and Manzanares.

Keywords: PTSD; cannabidiol; mRNA; mice model; sertraline.

Conflict of interest statement.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.