cbda vs cbdDecember 15, 2021
CBDA is also thought to be a powerful treatment for nausea and anxiety. A 2013 study from scientists in Guelph, Canada, found that CBDA was a thousand times more powerful than CBD in binding to a specific serotonin receptor linked to anti-nausea and anti-anxiety effects when administered alongside low-doses of the traditional anti-nausea drug for chemotherapy patients, ondansetron (OND).
The potential therapeutic use of CBDA.
CBDA benefits and medical use.
“We have taken the unstable acid molecules of the cannabis plant and synthesized them to provide a stable, consistent basis for researching new therapies across a wide range of medical needs – from central nervous system disorders to inflammation and many more,” Mechoulam said in a statement .
Like what you just read? You can find similar content on the topic tag shown below.
By comparison, CBDA has attracted much less attention from the public, the scientific community, and the media, despite being the precursor to CBD formation and showing promise in early pre-clinical research. But now, a trend of raw juicing cannabis and the advertisement of combination CBD and CBDA cannabis oils has thrust CBDA back into the spotlight, leaving many wondering what exactly is the difference between the two similarly named compounds.
Once CBDA has been formed, it’s then converted into CBD by thermal decarboxylation, whereby heat causes the molecule to lose its acidic carboxyl group. This decarboxylation process can either happen instantly , such as when the cannabis material is lit and smoked or vaporized, or by slow degradation over time if the plant material is left to sit at room temperature.
But new research is beginning to challenge this idea.
But why would people go to such lengths to get a dose of CBDA in the first place? What does the raw CBD precursor offer that CBD itself does not?
From here, plant enzymes unique to each cannabis strain convert CBGA into some varying combination of the three major cannabinoid precursor compounds: tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA), cannabidiolic acid (CBDA).
What is CBDA?
“In addition, we have provided several delivery mechanisms including tablets, topical applications and others to facilitate several approaches,” said Mechoulam. “Our work is a catalyst for the development of potential new therapies from a source long thought to have huge potential.”
Despite its demonstrated therapeutic potential, CBDA has not normally been considered as a viable clinical treatment. Naturally, it’s quite an unstable compound – as seen by its gradual decarboxylation at room temperature – and so it wasn’t considered a viable option for clinical treatment.
Cannabidiol (CBD) and cannabidiolic acid (CBDA) are both well-known and abundant chemical compounds native to the cannabis and hemp plant.
Conversion of cannabigerolic acid (CBGA), to cannabidiolic acid (CBDA), to cannabidiol (CBD).
It all began in 2008, when researchers noticed that the molecular structure of CBDA closely resembled that of other common nonsteroidal anti-inflammatory drugs (NSAIDs). The team then investigated the potential of CBDA to act as an anti-inflammatory agent and found that CBDA demonstrated the same COX-2 inhibitor behavior that enables NSAIDs to tackle inflammation.
Normally, CBDA and the other acidic forms of cannabinoids are not considered to be pharmacologically active . This is because they don’t affect the body’s endocannabinoid system in the same way that their decarboxylated forms do. As a result, most research has focused on the effects of CBD and THC, rather than CBDA and THCA.
The discovery was made by an international collaboration of scientists from several universities in Israel, Canada, and the United States, a topical cream manufacturer, a testing lab, and the start-up company EPM.
So, despite being abundant in raw cannabis, cannabis users are not actually exposed to much CBDA, as it’s converted from its “raw” form into CBD by most of the common consumption methods. For people who want to be consuming CBDA, this means having to use more uncommon or conventional consumption methods, such as topical creams, tinctures, and joining in on the raw cannabis juice trend.
CBDA is the chemical precursor to CBD. But even before CBDA, the mother of all cannabinoids, cannabigerolic acid (CBGA), is key.
CBD, the major non-psychoactive cannabinoid in cannabis, has been well investigated for its suspected therapeutic potential, and is currently thought to be able to treat epilepsy , inflammation , anxiety disorders , and a number of other common physical and neuropsychiatric conditions.
Roger Pertwee, an emeritus professor at the University of Aberdeen, detailed CBDA’s therapeutic potential to Analytical Cannabis in a recent episode of our Teach Me in 10 series. Here’s what he had to say:
Synthesis of cannabidiolic acid metal ester, HU-580 (right) from cannabidiolic acid, CBDA (left).
Alexander Beadle has been working as a freelance science writer since 2017 and has covered the cannabis industry for Analytical Cannabis since 2018. He has also written for our sister publication, Technology Networks, and the cannabis industry consultant firm Prohibition Partners, among others. Alexander holds an MChem in materials chemistry from the University of St Andrews, where he won a Chemistry Purdie Scholarship and conducted research into zeolite crystal growth mechanisms and the action of single-molecule transistors.
But new research from Dr Raphael Mechoulam – the cannabis scientist who first synthesized THC and CBD – may have broken down that barrier. Speaking at the CannMed 2019 conference in California last month, Dr Mechoulam announced that his research team has found a way to transform the unstable CBDA into a more stable compound which retains the therapeutic potential of CBDA.
The latter has now opened its intellectual property portfolio to the healthcare industry for licensing partnerships, in the hopes of attracting further investment. The company hopes that the compound will begin Phase 1 FDA clinical trials within the next six to twelve months.
While there has been a lot more scientific research on CBD than CBDA, it is starting to become a cannabinoid of interest. And just like other cannabinoids, CBDA can be used in products for therapeutic use.
The medicinal use of CBD is becoming more common every day, and research shows that it is a safe substance with seemingly endless beneficial health effects. Many people use CBD for pain relief. It binds with cannabinoid receptors in the brain and body to reduce inflammation and numb pain. This also makes it great for things like arthritis, injuries, and overall aches and pains. CBD is also popular for boosting mood, reducing anxiety and depression, and getting a good night’s sleep. Research also shows that it can help fight cancer by reducing cancer cells’ growth, and it helps reduce nausea for cancer patients going through chemotherapy.
Both CBD and CBDA can be found in oils, tinctures, topicals, and other easy-to-use products. But some users juice the leaves of fresh cannabis to get the freshest form of cannabidiolic acid. Both CBD and CBDA can provide a lot of similar health benefits, and using them depends on your personal preferences and which one is better at helping your symptoms. The best approach is to use them together. Like other cannabinoids, they work very well when combined and can boost each other’s benefits through what’s known as the entourage effect.
How Does CBD Affect the Body?
We are learning that CBDA also provides positive health effects a lot like CBD. And while the two are closely related, they actually work in different ways. CBDA doesn’t bind to cannabinoid receptors the way that CBD does. But it does interact with the body’s endocannabinoid system and boots serotonin production. Studies show that CBDA can act as a COX-2 inhibitor, making it great for reducing inflammation and pain. It can also work as an antiemetic and help fight feelings of nausea and vomiting. One study even found that it works better than CBD at reducing nausea. It also has antidepressant-like effects, can help with sleep, and be used to treat epilepsy.
Cannabidiolic acid is a type of compound found in cannabis called a cannabinoid. CBD is also a cannabinoid, but you won’t find much CBD if you look at a fresh cannabis plant. Instead, you would see abundant amounts of CBDA. CBDA is a compound that eventually becomes CBD. While CBD comes from grown and cured cannabis plants, CBDA occurs in plants that are still growing. CBDA is what’s known as an acid precursor of CBD and only comes about when raw cannabis containing CBDA is heated, causing what’s known as decarboxylation.
While the cannabis plant contains over 100 different cannabinoids, THC and CBD tend to be the ones most commonly talked about. But there are many other cannabinoids that provide unique benefits for the body. One of the lesser-known ones is CBDA or cannabidiolic acid. And while it is similar to CBD, the two have their own unique properties. So what is CBDA, and how is it different from CBD? Here’s a guide on CBDA vs CBD, their effects, and how to use them.
CBD and CBDA have many similarities, but since they work in the body differently, CBDA may be better at relieving certain symptoms than CBD. And science is just starting to learn about CBDA’s unique benefits.
Ready to see what CBD and CBDA can do for you? Come down and see us at one of our dispensary locations and our friendly budtenders will be happy to help you find the products that are right for you!