do you build a tolerance to cbdDecember 15, 2021
It is easy to surprise yourself in reading about cannabidiols’ potential benefits, especially regarding its ability to avoid the development of tolerance. It turns out that developing tolerance to CBD is a very different process than developing a tolerance for THC, and it’s nearly polar opposite. Instead of developing a chemical tolerance, CBD users experience what’s known as a reverse tolerance. In the case of reverse tolerance, continued use of CBD actually results in a smaller and smaller dose being needed to achieve the same effects as time progresses. As previously mentioned, compounds found in cannabis and hemp plants work closely with the endocannabinoid system by attaching themselves to endocannabinoid receptors. While THC diminishes the effectiveness of these receptors with repeated use, and over a long period of time, CBD promotes increased activity in these receptor cells. More specifically, this means that CBD users don’t face a breakdown of the interaction that cannabidiol has within the endocannabinoid system, so it can stay continually active without diminishing its own effectiveness. Many CBD users have reported using lower doses as time goes on because lower doses were ultimately needed to achieve the desired effects. Considering this, CBD may prove to be a benefit for anyone interested in using it in their daily lives.
As people have begun looking to cannabidiol (CBD) for its potential benefits, questions have inevitably arisen regarding the implications of introducing a new chemical into your system. Whether you’re using full spectrum CBD oil or isolate CBD, these extracts come from plants and so many consumers may be concerned with what this all means regarding any addictive qualities. The good news is that the source of a chemical usually doesn’t matter much regarding this property, it all comes down to how the chemical interacts in the body. Cannabis and hemp products, including CBD, interact directly with the endocannabinoid system. Regular cannabis users may be familiar with the compound THC, a psychoactive composite that is predominantly present in the cannabis plant. CBD, however, is the second most potent compound in the plant and the most prevalent chemical in the hemp plant. While THC users may be familiar with the body’s ability to develop a tolerance to the psychoactive nature of this compound, it’s reasonable to wonder if CBD can have a similar effect. Considering both THC and CBD are so closely related, it is easy to assume that they work in similar fashions. In reality, these chemicals work very differently from one another, and an inability to develop tolerance may be another potential reason to consider CBD as a new healthy additive to your lifestyle.
As is the case with most factors related to CBD, further research needs to be done. The growth and development of the industry should prove fruitful for this sort of vital information as companies, and other entities, are able to engage in more research to support these claims. That being said, as is recommended with any new supplemental diet changes, it is advised that you take precautions when approaching your schedule of CBD usage. Additionally, while your CBD dosage may fluctuate over time, it may interact with other medications that you are using to treat certain ailments. Proceed with caution and always consult a physicianl with questions about your own health. Stay soothe!
Reverse tolerance, also called drug sensitization, means that less of something is needed to get to the same end point. This is the opposite of tolerance. A smaller dose is needed and, in some cases, continues to slowly decrease.
“ I’m taking CBD products on a regular basis but will I start to build up a tolerance and eventually need to take more CBD to get the same benefits? ” For the savvy person using CBD for its powerful benefits, concerns about CBD tolerance is a fair one given that THC (the psychoactive component in marijuana) is well-known for building up tolerance in users. But when it comes to CBD, the answer is a straight-up “no”.
Everyone’s body is different depending on your genetic makeup—which is why figuring out the correct dosage of CBD requires some personal experimentation. Now, assuming you’re using a high-quality CBD product (and not fake CBD ), take a look at our helpful CBD dosage post to begin to work out your CBD “sweet spot”.
Even though CBD and THC come from the same cannabis plant species, CBD does not cause tolerance because it doesn’t work by binding to the cannabinoid receptors in the same way that THC does. CBD avoids the problem of tolerance altogether and, unlike THC which reduces cannabinoid receptors over time, CBD actually promotes increased receptor activity. In fact, some people have reported that after a few months of CBD with desired results, they find that they don’t need as much, and decrease their dose without the loss of effects (hello, reverse tolerance!).
Research shows that long-term and regular use of THC results in users building up a tolerance because of the way that it binds directly to the body’s endocannabinoid receptors . These receptors are part of the endocannabinoid system which controls the immune system, nervous system, and mood. In particular, THC binds strongly to the CB1 receptor in the brain (hence the mind-altering experience) and chronic THC users have fewer cannabinoid receptors over time, therefore needing more THC to get the same result.
Why Does THC Cause Tolerance?
“I’m using CBD on a regular basis, kind of like a vitamin, but will I start to build up a tolerance and eventually need to take more CBD to get the same benefits?” For the savvy person using CBD for therapeutic benefits, concerns about CBD tolerance is a fair one given that THC (the psychoactive component in marijuana) is well-known for building up tolerance in users. But when it comes to CBD, the answer is a straight-up “no”.
In fact, when it comes to CBD, in some cases the opposite is true (known as reverse tolerance ). It’s crucial to have all the facts on hand so you can continue to take CBD with confidence and assurance so let’s break this down:
Tolerance occurs when you start to see less benefits with a previously effective amount. The result of developing a tolerance is that you start to need more of something to get the same desired effect.
Understanding tolerance and reverse tolerance when it comes to CBD is another crucial part of your wellness journey. Having all the facts to hand, being able to troubleshoot when needed, dispelling CBD myths , and ultimately getting to know your body’s unique set of responses will continue to put you in the power seat to wellbeing and, ultimately, peace of mind.
Tolerance? Reverse Tolerance? Huh?
Why Doesn’t CBD Cause Tolerance (When THC Does)?
Whatever the reason for CBD’s reverse tolerance, patients will find that they can slowly decrease their dosage over time.
Long-term use leads to an internal response from the endocannabinoid system, and our bodies adapt to the continual presence of the compound, and as such, a higher dosage is required to achieve the same effect.
CBD promotes increased receptor activity, unlike THC, which reduces cannabinoid receptors over time.
After a break from THC, the same users returned to lower dosages, and their cannabinoid receptor levels had returned to normal.
There is, however, something to be aware of, called CBD saturation. This is often found in users taking CBD oil for epilepsy.
How Does Reverse Tolerance Work?
Another significant difference between the two is the risk of tolerance. The main issue with THC is that when used for medicinal or recreational purposes, there is a slow increase in levels of tolerance.
Oddly enough, it seems to have the opposite effect. A bizarre phenomenon called reverse tolerance.
In some rare cases with alcohol, the opposite is experienced due to severe liver damage.
Most substances cause people to experience increased tolerance levels. Everything from pharmaceuticals, nicotine, alcohol, and hard drugs like cocaine and methamphetamines.
Some personal reports are online where people claim to have experienced CBD tolerance when taking it for anxiety.
The initial dose will eventually become ineffective when taken regularly. CBD does not seem to trigger a tolerance.
Just as the name suggests, reverse tolerance is the opposite of tolerance to CBD.
As CBD is a cannabinoid the same as THC, it would be natural to assume that it has many of the same tendencies, including building up a tolerance.
Over time THC reduces the number of available cannabinoid receptors.
The truth is that CBD and THC share a few traits (they both affect the endocannabinoid system, for example), but they are, in fact, very different.
How Does Tolerance Develop in the First Place?
Tolerance develops most commonly with drugs that bind directly to our endocannabinoid receptors (THC being an example).
There are major differences between CBD and THC. CBD has become very popular for its ability to treat anxiety, which THC is known to trigger. CBD also doesn’t trigger psychoactivity, which THC infamously does.
Research has shown that long term THC use leads to increased tolerance. THC binds strongly to the cannabinoid receptor CB1, which is responsible for the psychoactive effect.
So to conclude, CBD tolerance is most likely nothing to worry about.
Common sense would dictate at that point that a higher dosage may be needed, but there is evidence to suggest that the opposite may be the answer, and a lower dose or simply a break from CBD oil could help restore its effectiveness.
Continued use of a substance brings tolerance levels down, and the user needs less of the substance to achieve the desired effect.
After long-term CBD use, the users may begin to experience seizures again.
Personal Anecdotes about CBD Oil Tolerance.
However, on closer inspection, some of these complaints were down to users struggling to find a high-quality source of CBD oil.
Interested in experiencing the potential benefits of CBD oil for yourself? Check out our Full Spectrum CBD oil here.
Other receptors, such as GABA receptors and NMDA receptors, also respond to CBD and have also been shown to play a part in reverse tolerance.
This is because CBD does not technically bind to any single one cannabinoid receptor, eliminating the problem of tolerance.
(You may also find this article looking at the pros and cons of CBD oil useful to read).
This was support by a study conducted in 2012, which showed that chronic THC users had fewer cannabinoid receptors than non-users.
There are only limited studies into the tolerance of CBD, but the general consensus is that there is little to no risk of developing a tolerance.
The truth is that more research needs to be conducted about tolerance to CBD oil. However, in the meantime, users have been able to find their own solutions with great results.