how does cbd hemp oil workDecember 15, 2021
In 2018, the Food and Drug Administration (FDA) approved the use of CBD under the brand name Epidiolex to treat seizures resulting from Lennox-Gastaut syndrome and Dravet syndrome—two rare forms of epilepsy—in patients at least 2 years old.
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In some instances, CBD can be used to treat epileptic seizures.
1. Offset Anxiety and Depression.
A 2006 study found that Sativex—a CBD-based botanical drug approved in the United Kingdom in 2010—promoted statistically significant improvements in quality of sleep, pain during movement and pain at rest in patients with rheumatoid arthritis when compared to a placebo. It was the first controlled trial of Sativex as a treatment for rheumatoid arthritis, involving 58 patients. CBD was found to have a pain-relieving effect, as well as an ability to suppress disease activity.
When introduced topically, CBD oil doesn’t affect the systemic issue as it might if it were introduced directly into the bloodstream. Instead, topical CBD is more localized and treats pain in a certain area. Since it’s more direct, it may have a more pronounced effect.
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Meanwhile, continued studies in the U.S. indicate CBD is effective in treating chronic, non-cancer pain. In one 2020 study, researchers administered CBD topically to a group of patients with symptomatic peripheral neuropathy (a result of brain nerve and spinal cord nerve damage) while another group with the same condition received a placebo. Results showed a significant reduction in intense, sharp pains and cold, itchy sensations in those who used the topical CBD compared to those who used the placebo. No participants reported adverse side effects.
Meanwhile, at least one study in mice revealed CBD had effects similar to the antidepressant imipramine. Human trials are needed, though, to confirm whether CBD can induce this same antidepressant reaction in our bodies.
Research suggests people with ALS can benefit from the entourage effect created by the combination of THC and CBD, similar to people with PTSD. In a 2019 study, patients received a combination of THC and CBD in varying doses depending on their needs and preferences. Those with mild, moderate or severe spasticity (muscle tightness and stiffness) due to ALS reported high levels of satisfaction with the treatment, and those with moderate to severe spasticity reported higher satisfaction rates than those with mild spasticity.
Preclinical and clinical studies show that CBD has antioxidant and anti-inflammatory properties. Researchers deduce these characteristics can provide significant neuroprotection, or protection against numerous pathological disorders.
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In another small study, 13 patients with type 2 diabetes who weren’t on insulin treatment were given both CBD and a placebo (in lieu of insulin). Researchers found CBD decreased their levels of resistin (which causes resistance to insulin, the protein that regulates sugar levels) and increased their levels of glucose-dependent insulinotropic peptide (a hormone that ensures a sufficient release of insulin from digested food) compared to their baselines before they started the test. These results suggest CBD could be a natural treatment for diabetes by helping the body regulate insulin-related hormone levels.
In 2005, Canada approved the use of Sativex, an oromucosal (absorbed in the lining of the mouth) spray with equal proportions of THC and CBD, for the treatment of multiple sclerosis-related central neuropathic pain. In 2007, Canada approved the medicine’s use again for cancer pain that proved unresponsive to other medications.
Other studies find CBD helpful in reducing various psychiatric and medical symptoms like anxiety, insomnia and pain in patients with substance use disorders, indicating that CBD may be an effective treatment for opioid addiction. However, further studies are necessary.
Margaret Rajnic, a doctor of nursing practice experienced in medical cannabis and CBD, emphasizes the importance of using therapy in tandem with any type of cannabis or CBD for PTSD. “There is an amount of therapy that is needed for PTSD,” she says. “But CBD will give you that little bit of decreased anxiety.”
In one such study, researchers administered CBD to people with heroin use disorder. Over the course of a week, CBD significantly reduced heroin users’ cue-induced cravings, withdrawal anxiety, resting heart rate and salivary cortisol levels. No serious adverse effects were found.
2. Treat Select Epilepsy Syndromes.
Arthritis involves the deterioration of the tissues in and around your joints. There are several types of arthritis, and symptoms include pain, stiffness and loss of motion. Arthritis treatment usually targets pain relief and improved joint function.
Four other human trials from 2012 to 2016 suggest CBD reduces PTSD symptoms, although some include THC, or tetrahydrocannabinol, the main mind-altering element in cannabis. When THC and CBD work together, they create what’s called an “entourage effect,” complementing each other’s benefits and potency. For example, taking the same dose of THC and CBD together tempers the “high” from THC, while just a little THC paired with more CBD enhances the effects of the CBD.
Several preclinical studies suggest CBD can produce beneficial effects against Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Huntington’s disease and cerebral ischemia were also tested, although significant positive results were not recorded. Further clinical studies are needed to confirm CBD’s benefits when used as a treatment for these disorders.
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CBD is often extracted from the cannabis sativa plant in oil form and mixed with an inert carrier oil like hemp seed oil for consumption. In recent years, CBD oil has skyrocketed in popularity thanks to its purported calming effects. It can now be found in a range of products from simple oil tinctures to CBD-infused potato chips.
Unlike THC, CBD doesn’t have a strong connection with cannabinoid receptors in the brain. These are the molecules that THC binds to create psychoactive effects.
Epidiolex is used to treat two rare forms of epilepsy in children under 2: Dravet syndrome and Lennox-Gastaut syndrome. These are very rare genetic disorders that cause lifelong seizures that start in the first year of life.
Of course, never make changes to your medication regimen without your doctor's OK.
To avoid interactions, tell your healthcare provider and pharmacist what medicine you're taking. This includes prescription, over-the-counter, herbal, or recreational drugs.
If you're thinking of using CBD oil to treat a health condition, talk to your healthcare provider to make sure it's an appropriate option for you.
Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.
CBD oil contains CBD mixed with a base (carrier) oil, like coconut oil or hemp seed oil. The bottled CBD oil is called a tincture and is sold in different concentrations.
However, there aren't many studies that examine the use of CBD in treating chronic pain in people. The studies that do exist almost always include THC. This makes it hard to isolate CBD's unique effects.
Don't drive or use heavy machinery when taking CBD oil since some of them contain THC. This is especially important when you first start treatment or use a new brand.
CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should consult their healthcare provider before taking CBD oil and use it with caution. Regular blood liver enzyme level checks are recommended.
Some experts suggest CBD may help treat cannabis and nicotine dependence, but more research is needed.
The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL (or more).
You might experience nausea, diarrhea, or dizziness when you take CBD oil. Don't take CBD oil if you're pregnant or breastfeeding. Also, CBD oil affects the way your body breaks down certain drugs, so talk to your healthcare provider if you're on any medications.
How to Calculate CBD Dose.
The study authors report that CBD had powerful anxiety-relieving effects in animal research. But the results weren't what you'd expect.
This article goes over what CBD is used for, possible side effects, and what you should look for if you choose to buy CBD.
Alternative medicine practitioners believe these compounds provide more important health benefits, but there's no clear evidence to support this.
CBD's exact mechanism of action is unclear.
Cytochrome P450 (CYP450) is an enzyme in your body that breaks down certain drugs. But CBD oil can block CYP450 from working the way it normally does. CBD oil can either make some drugs you take have a stronger effect than you need or make them less effective.
In studies, the CBD in hemp oil has been shown to reduce seizures in rare types of childhood epilepsy that are resistant to other treatments, Dravet syndrome and Lennox-Gastaut syndrome. Regularly taking CBD can also reduce the number of seizures brought on by tuberous sclerosis complex, a condition that causes tumors to form throughout the body.
Brain, Behavior, and Immunity : “Omega-3 Supplementation Lowers Inflammation and Anxiety in Medical Students: A Randomized Controlled Trial.”
Potential Health Benefits of Hemp Oil.
Many of these nutrients provide the body necessary minerals and also contribute to overall health. Note that hemp seeds contain a significant amount of iron (20 % of your recommended daily diet). This helps prevent iron deficiency, or anemia.
In addition to CBD, Hemp oil contains large amounts of omega-6 and omega-3 fats, which are two types of unsaturated fat s, or “good fats,” and all nine essential amino acids, the materials your body uses to make protein. Here’s more information about nutrients in hemp seed oil and how they may benefit your health.
Mayo Clinic Proceedings : “Clinicians’ Guide to Cannabidiol and Hemp Oils.”
Hemp oil, also known as hemp seed oil, is made from hemp, a cannabis plant like the drug marijuana but containing little to no tetrahydrocannabinol (THC), the chemical that gets people “high.” Instead of THC, hemp contains cannabidiol (CBD), a chemical that has been used to treat everything from epilepsy to anxiety.
Some people experience skin irritation when using topical oils containing CBD, possibly due to an allergy. Start with using a small amount to see how your skin reacts to it, and keep an eye on any changes.
Hemp oil is made from hemp seeds. In one serving of hemp seeds (3 tablespoons), you’ll find the following:
The amino acid arginine is present in hempseed oil. Studies have shown that this ingredient contributes to a healthy cardiovascular system. Consuming foods with high arginine levels can help decrease the risk of heart disease.
Journal of Dermatological Treatment : “Efficacy of dietary hempseed oil in patients with atopic dermatitis.”
Hemp is increasingly popular as a remedy for a range of conditions including skin issues and stress. It may contain properties that contribute to reduced risks of illnesses like Alzheimer’s disease and cardiovascular disease, though additional research is necessary. Hemp oil may also reduce inflammation in the body.
Although hemp and marijuana come from the same species of cannabis plant, hemp has little to no THC. This means that consuming hemp is legal in the U.S. and will not cause you to become intoxicated or impaired.
GW Research Ltd.: “A Randomized Controlled Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6).”
Over time, excess inflammation in your body can contribute to a variety of diseases including heart disease, diabetes, cancer, and asthma. It has been suggested that gamma linolenic acid, an omega-6 fatty acid found in hemp, acts as an anti-inflammatory. Studies have also linked the omega-3 fatty acids in hemp with reductions in inflammation.
Hemp seed oil is used as a remedy for a range of conditions. Some studies show that its nutrients and minerals can contribute to better skin and heart health as well as reduced inflammation. Here’s a deeper look at what the research says about the potential health benefits of hemp oil:
Journal of Clinical Investigation : “Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.”
Harvard Men’s Health Watch: “Iron and your health.”
It’s possible that ingesting CBD-containing oils like hemp oil can cause an upset stomach or diarrhea. Again, when you’re first introducing hemp oil into your diet, start small to see how it impacts you. Reactions may be different from person to person.
Current Pharmaceutical Biotechnology : “Gamma linolenic acid: an antiinflammatory omega-6 fatty acid.”