what does cbd do to your brainDecember 15, 2021
CBD acts on the CB2 receptors to decrease the level of oxidative damage. Possessing strong antioxidant abilities, researchers believe that cannabidiol’s neuroprotective antioxidant capacity is similar to that of Vitamins C and E.
The cannabis plant contains over 110 cannabinoids that bind with ECS receptors. The two main receptors are CB1 and CB2, although scientists believe there may be more. CB1 receptors are prevalent in the CNS and regulate pain, appetite, mood, coordination, and other functions. CB2 receptors are prevalent in the body and immune system, and primarily affect pain and inflammation.
THC, the cannabinoid associated with a psychotropic high, is intoxicating — CBD is not.
While scientists are not completely sure, they believe that CBD also affects the way in which these receptors respond to the pain signals we receive, which helps reduce pain and inflammation.
Our body responds to the creation of free radicals by using antioxidants to stabilize the waste and ensure they don’t cause damage to the DNA in our cells. However, if the free radicals are too numerous and we don’t produce enough antioxidants, the waste products begin stealing DNA particles. This process can result in the development of conditions such as Alzheimer’s, Parkinson’s, and atherosclerosis.
2 – CBD Works to Manage Pain.
When you consume cannabis, the plant’s cannabinoids bind to the receptors in a manner akin to a key fitting into a lock. The receptors that are affected and parts of the brain that get involved vary from person to person depending on factors such as previous drug use and genetic make-up.
Ultimately, cannabidiol is one of the fastest-growing supplements in the world at present. Consumers are turning to CBD to manage conditions such as migraines, brain fog, anxiety, depression, and chronic pain. As the popularity of CBD increases, so does the number of anecdotal accounts regarding its efficacy, not to mention a significant rise in scientific studies.
Our endocannabinoid system (ECS) consists of numerous endocannabinoids; these are neurotransmitters that bind to receptors throughout our CNS and peripheral nervous system. Our ECS helps regulate a variety of cognitive and physiological processes in the body, such as memory, pain, stress response, and appetite.
Those who suffer from chronic pain are using CBD in the belief that the cannabinoid can help manage the symptoms. CBD modifies CB2 receptors’ ability to bind endocannabinoids. Alternatively, it may cause the body to produce more of the natural cannabinoids that attach to the CB2 receptors.
The brain has protein receptors throughout it that respond to endocannabinoids.
Now that we have explored a little of the science behind CBD’s effects; let’s look at five specific ways it impacts the human brain.
Fatty acid amide hydrolase (FAAH) breaks down anandamide. However, CBD inhibits the FAAH enzyme, which means the bliss molecule remains active in the ECS for longer; thus enhancing its potency.
In reality, psychoactive chemicals act on the central nervous system (CNS) and alter brain function. As a result, they cause temporary changes in consciousness, behavior, mood, or perception. CBD impacts mood and other behaviors, so there are psychoactive effects. In this guide, we illustrate five of them.
THC closely mimics a naturally occurring cannabinoid named anandamide which binds to the CB1 receptors, which are responsible for many of THC’s psychoactive effects. As the psychoactive cannabinoid binds to anandamide’s CB1 receptors even more closely than anandamide, which is known as ‘the bliss molecule.’ It inhibits the release of other neurotransmitters. This helps explain the feelings of euphoria associated with the ‘high’ from cannabis.
A study by Pretzsch et al. , published in the Neuropsychopharmacology journal in February 2019, looked at the effects of CBD on brain excitation and inhibition systems. The team concluded that CBD could ‘shift’ the level of Glx and GABA+ metabolites; they are known to contribute to the regulation of inhibitory and excitatory neurotransmission in the autistic and typical brains. The researchers pointed out that further studies were required.
A study by Crippa et al. , published in the Journal of Psychopharmacology in September 2010, looked at the effects of CBD on a small group of subjects with Social Anxiety Disorder (SAD). The researchers discovered that the participants felt better, and CBD helped change the way their brains responded to anxiety. What’s fascinating; the brain scans revealed changes in blood flow to the areas of the brain usually linked with anxiety.
Excitotoxicity is the damage caused when our brain cells become overactive due to excessive stimulation. It can result from traumatic brain injury, stroke, hearing loss, and neurodegenerative diseases of the CNS, including multiple sclerosis and Alzheimer’s.
The CBD industry continues to grow at an extraordinary rate. However, there is still a remarkable amount of misinformation when it comes to the cannabinoid. One of the biggest mistakes relating to CBD is the notion that it is non-psychoactive. In reality, cannabidiol is non-intoxicating , and there is a BIG difference.
A study by Cheng et al. , published in the Journal of Alzheimer’s Disease in 2014, found that long-term CBD treatment “prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice.” The researchers also wrote that CBD exerts anti-inflammatory, antioxidative, and neuroprotective properties in vitro and in vivo.
This benefit relates to CBD’s effects on anandamide. Anandamide was discovered in the 1990s and is a neurotransmitter that can both improve mood while also potentially reducing pain sensitivity.
How Does CBD Affect Your Brain?
CBD’s antipsychotic effects relate to its impact on anandamide. Scientists link higher levels of the bliss molecule with a decrease in psychotic symptoms. A study by Leweke et al. published in Translational Psychiatry in March 2012, looked into the effect of CBD on anandamide production.
CBD has a much milder effect on the receptors. It only binds itself to the CB1 receptors loosely and results in the blocking of the receptors, mitigating THC’s psychoactive effects. CBD also inhibits anandamide degradation, which leads to increased circulating levels of the molecule.
Glutamine-dependent excitotoxicity is seen in practically every age-related neurodegenerative disease and brain disorder. It also happens to be one of the main molecular mechanisms noted in epilepsy. In recent times, there has been an increasing level of research into CBD as a treatment for neurodevelopmental disorders such as autism spectrum disorder (ASD).
The way in which our bodies manage oxidative stress plays a huge role in maintaining good health. Oxidative stress is a natural process that happens at a cellular level. When a cell generates energy, it generates free radicals as a waste product. Environmental toxins, such as smog exposure, can also create free radicals.
The cannabinoid’s effects on the brain appear to be many and profound, but we need more confirmatory studies. We advise all readers to steer clear of CBD sellers that try to portray cannabidiol as a ‘cure-all.’ There is no question that the existing research is exciting, but it would be irresponsible to draw too many conclusions just yet.
The researchers wrote that an elevation of anandamide levels in cerebrospinal fluid inversely correlates to psychotic symptoms. The team performed a double-blind, randomized trial of CBD versus a potent antipsychotic. Ultimately, the study found that CBD boosted anandamide signaling and alleviated the psychotic symptoms of schizophrenia.
However, we still need further clinical trials involving humans to confirm CBD’s positive neurological effects.
Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level of blood thinning and other medicines in your blood by competing for the liver enzymes that break down these drugs. Grapefruit has a similar effect with certain medicines.
CBD, or cannabidiol, is the second most prevalent active ingredient in cannabis (marijuana). While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, a cousin of marijuana, or manufactured in a laboratory. One of hundreds of components in marijuana, CBD does not cause a “high” by itself. According to a report from the World Health Organization, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD.”
Cannabidiol (CBD) is often covered in the media, and you may see it touted as an add-in booster to your post-workout smoothie or morning coffee. You can even buy a CBD-infused sports bra. But what exactly is CBD? And why is it so popular?
Animal studies, and self-reports or research in humans, suggest CBD may also help with:
People taking high doses of CBD may show abnormalities in liver related blood tests. Many non-prescription drugs, such as acetaminophen (Tylenol), have this same effect. So, you should let your doctor know if you are regularly using CBD.
The evidence for cannabidiol health benefits.
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, stop them altogether. Epidiolex, which contains CBD, is the first cannabis-derived medicine approved by the FDA for these conditions.
Some CBD manufacturers have come under government scrutiny for wild, indefensible claims, such that CBD is a cure-all for cancer or COVID-19, which it is not. We need more research but CBD may prove to be a helpful, relatively non-toxic option for managing anxiety, insomnia, and chronic pain. Without sufficient high-quality evidence in human studies, we can’t pinpoint effective doses, and because CBD currently is typically available as an unregulated supplement, it’s hard to know exactly what you are getting.
CBD is readily obtainable in most parts of the United States, though its exact legal status has been in flux. All 50 states have laws legalizing CBD with varying degrees of restriction. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. In 2018, the Farm Bill made hemp legal in the United States, making it virtually impossible to keep CBD illegal – that would be like making oranges legal, but keeping orange juice illegal.
A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So, you cannot be sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other unknown elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.
The Farm Bill removed all hemp-derived products, including CBD, from the Controlled Substances Act, which criminalizes the possession of drugs. In essence, this means that CBD is legal if it comes from hemp, but not if it comes from cannabis (marijuana) – even though it is the exact same molecule. Currently, many people obtain CBD online without a medical marijuana license, which is legal in most states.
CBD comes in many forms, including oils, extracts, capsules, patches, vapes, and topical preparations for use on skin. If you’re hoping to reduce inflammation and relieve muscle and joint pain, a topical CBD-infused oil, lotion or cream – or even a bath bomb — may be the best option. Alternatively, a CBC patch or a tincture or spray designed to be placed under the tongue allows CBD to directly enter the bloodstream.
Outside of the US, the prescription drug Sativex, which uses CBD as an active ingredient, is approved for muscle spasticity associated with multiple sclerosis and for cancer pain. Within the US, Epidiolex is approved for certain types of epilepsy and tuberous sclerosis.
If you decide to try CBD, make sure you are getting it from a reputable source. And talk with your doctor to make sure that it won’t affect any other medicines you take.